摘要：探讨牡蛎蛋白酶解物（Enzymatic hydrolysates from oyster protein,以下简称EHOP）改善小鼠学习记忆能力及...探讨牡蛎蛋白酶解物（Enzymatic hydrolysates from oyster protein,以下简称EHOP）改善小鼠学习记忆能力及其体内抗氧化活性。选用中性蛋白酶和碱性蛋白酶分别水解牡蛎蛋白得到EHOP1和EHOP2,按剂量5g/kg.d分别给4周龄小鼠灌胃4周后,通过Morris水迷宫方法考察了EHOP对小鼠空间学习记忆功能的影响,并检测小鼠肝组织和脑组织中SOD活性及MDA含量。结果表明,与空白组相比,EHOP1组和EHOP2组小鼠的潜伏期（分别为18.97±3.84s、22.61±4.04s）均明显缩短,采用空间搜索策略的比例、穿越平台的次数、目标象限停留的时间和路程均有不同程度的增加。与空白组相比,EHOP能够显著增强小鼠肝组织中SOD活性（P〈0.005）,显著性减少脑组织及血浆中的MDA含量（P〈0.005）。结果显示,EHOP能够明显改善小鼠的空间学习记忆能力,具有良好的体内抗氧化活性。显示全部
摘要：This study was to determine the protective effect of ω-3 polyunsaturated fatty acids(ω-3PUFAs) on...This study was to determine the protective effect of ω-3 polyunsaturated fatty acids(ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia(SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons was measured by Nissl staining. The expression of CREB, p-CREB, BDNF, TrkB, p-TrkB, AKT, p-AKT, ERK, and p-ERK in the hippocampus of rats was detected by Western blotting. The results showed that ω-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. In conclusion, ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.显示全部
