作　　者： ;

机构地区： 暨南大学

出　　处： 《中国病理生理杂志》 2022年第8期1520-1525,共6页

摘　　要： 代谢性疾病是一类与遗传、环境、生活方式、运动等因素有关的病因复杂、病程缓慢且难以治愈的慢性疾病,包括糖尿病、肥胖、动脉粥样硬化、高血压等[1,2]。临床上将这种代谢紊乱引发的一系列病理现象统称为代谢综合征(metabolic syndrome,MetS),其特征是血糖升高、胰岛素抵抗和炎症、血脂异常、脂肪蓄积、血压升高、血栓形成等危险因素并存[2-3]。这些因素与患2型糖尿病(type 2 diabetes,T2MD)和心血管疾病(cardiovascular diseases,CVD)等慢性病的风险增加有关[4]。MetS促使动脉粥样硬化性心血管疾病(atherosclerotic cardiovascular disease,AS-CVD)的患病风险大约增加1倍,患糖尿病的风险增加了大约5倍,并且在成年人群中发病率很高. Piezo1,a mechanically activated ion channel,is widely expressed in various tissues. Piezo1 is activated by mechanical stimuli exerted on cellular membranes of tissues,upon which they rapidly and efficiently convert these stimuli into electrical and/or chemical intracellular signals,thus regulating the physiological functions. In recent years,studies focus on the role of Piezo1 in energy metabolism. Activation of Piezo1 channel induces insulin release fromβ-cell lines and mouse pancreatic islets. The mechanosensitive cationic channel Piezo1 mediates diet-induced adipogenesis. In addition,Endothelial cell Piezo1 mediates plaque formation,angiogenesis and regulation of blood pressure,thereby influencing the occurrence and development of metabolic diseases such as atherosclerosis and hypertension. This article reviews the research progress on Piezo1 and its role in energy metabolism. Illustration of the role of piezo1 in metabolism may provide new targets for the treatment of metabolic diseases such as diabetes,obesity,atherosclerosis,and hypertension.

关 键 词： 蛋白 代谢性疾病 糖尿病 肥胖 动脉粥样硬化 高血压

领　　域： [医药卫生—内分泌] [医药卫生—内科学] [医药卫生—临床医学]