作　　者： ;

机构地区： 深圳大学

出　　处： 《华南师范大学学报：自然科学版》 2011年第2期 1-6,共6页

摘　　要： 功能内稳态（FSH）用负反馈的方式维持功能特异的涨落，实现功能充分稳定的发挥．FSH特异的应激因子（FSSR）打破FSH-FSH特异的应激（FSH—specificstress，FSS）是系统对FSSR的响应，也可以处于FSS特异的内稳态（FSS—specifichomeostasis，FSSH）．处于FSSH的FSS打破FSH1，建立FSH2，称为成功应激．Sirtuin1（SIRT1）是烟酰胺腺嘌呤二核苷酸辅酶（nicotinamide adenine dinucleotide，NAD）依赖的组蛋白去乙酰化酶．人体存在FSH／FSSH特异的SIRT1活性．FSS可增加SIRT1活性．一个人可以同时有多种FSH，{FSH；，i=1，2，…，n}．每个FSH具有一个品质Q，{Q；，i=1，2，…，n}．定义Qmax=max{Qi，i=1，2，…，n}，相应的功能记为Fmax最佳品质结构是金字塔形，Qmax处于塔顶，只要Rmax可以获得最佳发挥，其它品质越小越好． Function -specific homeostasis （FSH） is a negative -feedback response of a biosystem to maintain the function- specific fluctuations inside the biosystem so that the function is perfectly performed. A stress is also a function of a biosystem. A FSH - specific stressor（FSSR） is so defined that it disrupts the FSH. A FSH - specific stress （FSS） of a biosystem is defined to be a response of the biosystem to a FSSR and may also be in FSS - specific homeostasis（FSSH） in which a FSS disrupt FSH1 but establish FSH2 so that it is called successful stress. There is FSH/FSSH - specific sirtuin 1 （ SIRT1 ） activity （ FSSA1 ）. SIRT1 is nicotinamide adenine dinucleotide （ NAD ＋ ） dependent, but NAD ＋ is limited by nutrition. A FSS increases SIRT1 activity so that FSSA1 is locally minimum. A person might simultaneously have many kinds of FSH, { FSHi, i = 1,2, …, n} , each of which has quality Q, { Qi ,i = 1,2,..., n } . Let Qmax = max { Qi,i = 1,2,..., n } and the corresponding function is Fmax,. The best structure of Q is a pyramidal hierarchy in which Qmax is at its peak but the other Q, are as low as possible if Fmax can be optimized.

关 键 词： 内稳态 应激 组蛋白去乙酰化酶 烟酰胺腺嘌呤二核苷酸辅酶

分 类 号： [Q411]

领　　域： []