作　　者： ; ;

机构地区： 广东省药品检验所

出　　处： 《医药导报》 2019年第3期359-364,共6页

摘　　要： 目的建立离子色谱-电感耦合等离子质谱联用技术分析沉香化气丸中不同形态砷(As)和六价铬Cr(Ⅵ)。方法以0.15 mol·L-1硝酸溶液为萃取剂,80℃恒温箱中热浸提法提取沉香化气丸中砷甜菜碱(As B)-二甲基砷酸(DMA)、三价砷As(Ⅲ)、砷胆碱(As C)、甲基砷酸(MMA)、五价砷As(V)等6种不同形态砷,磷酸氢二钾、磷酸二氢钾缓冲溶液与六水合氯化镁以及碱性提取液提取沉香化气丸中Cr(Ⅵ)。采用离子色谱-电感耦合等离子质谱直接测定相应含量。结果沉香化气丸药材中砷的形态主要以As(Ⅲ)、As(V)为主,毒性极强的Cr(Ⅵ)含量极低,不同形态As回收率92.4%～105.8%,Cr(Ⅵ)回收率101.29%。结论该方法灵敏,准确性好,是分离测试沉香化气丸中不同形态As和Cr(Ⅵ)的有效方法。 Objective To establish a method to analyze As-species and Cr(Ⅵ) in Chenxiang Huaqi pill by IC-ICPMS.Methods 0.15 mol·L-1 nitrate solution was applied as extractant at 80 ℃ in oven to extract six different As-species,which were As B,DMA,As,As C,(Ⅲ) MMA,As(V).K2HPO4-KH2PO4 buffered solution,MgCl2·6H2O and alkaline extract was applied to extract Cr(Ⅵ) from Chenxiang Huaqi pill.The content was determined by IC-ICP-MS.Results The result showed that the main species of arsenic in Cuscuta was As(Ⅲ) and As(V).The Cr(Ⅵ) level was extremely low.The recovery rate of As-species ranged from 92.4% to 105.8%,and recovery rate of Cr(Ⅵ) was 101.29%.Conclusion The method is sensitive,accurate and effective to separate and analyze As-species and Cr(Ⅵ) in Chenxiang Huaqi pill.

关 键 词： 沉香化气丸 砷 不同形态 铬 联用技术

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