作　　者： ; ;

机构地区： 中山大学新华学院

出　　处： 《广东化工》 2018年第20期29-30,共2页

摘　　要： 目的:制备小柴胡泡腾颗粒,并对其进行质量评价。方法:利用微波消解仪对小柴胡方剂进行提取,采用紫外分光光度法测定小柴胡泡腾颗粒中柴胡总皂苷a含量,并对其粒度、水分、溶化性、干燥失重相关指标进行考察。结果:采用微波消解仪提取药材,PEG6000、碳酸氢钠、乳糖与枸橼酸为辅料制备得到的小柴胡泡腾颗粒柴胡皂苷含量为10.09 mg/g(m_(柴胡皂苷)/m_(药材总量)),水分含量为3.19%,干燥失重1.84%,溶化性良好,粒度检测合格。结论:微波提取法效率高,小柴胡泡腾颗粒制备工艺简单可行,性质稳定,质量可控,可为生产提供依据。 Objective： Preparation and quality assessment of Xiaochaihu effervescent granules was carried out in order to improve the clinical applicability of the traditional decoction. Methods： The Xiaochaihu decoction was extracted by microwave assisted technology. Further evaluation such as drug content was determined by the concentration of saikosaponin A with ultraviolet spectroscopy, and the granule size, water, solubility, loss on drying were assessed with the Chinese pharmacopoeia 2015.Result：Effervescent granules prepared by PEG 6000, NaHCO3, lactose, citric acid and dry extract were evaluated with 10.09 mg/gsaikosaponin A concentration, 3.19 % water, 1.84 % loss on weight, good solubility and suitable granule size. Conclusion： The microwave assisted technology was highly effective for the extraction of Xiaochaihu decoction, as well as the quality of effervescent granules was stable and controllable. In a word, the preparation technology of Xiaochaihu decoction was simple and feasible, which may offer references for the industrial production.

关 键 词： 小柴胡 微波提取法 泡腾颗粒剂

领　　域： []