作　　者： (）;

机构地区： 广州市惠爱医院

出　　处： 《中国药业》 2019年第16期57-59,共3页

摘　　要： 目的比较艾司西酞普兰和舍曲林治疗躯体形式障碍的临床疗效。方法选取医院2015年1月至2017年9月收治的躯体形式障碍患者80例,按随机数字表法分为A组和B组,各40例。在心理干预基础上,A组患者给予盐酸舍曲林片,B组患者给予草酸艾司西酞普兰片,均连续治疗4周。结果治疗2周后,B组总有效率为82.50%,明显高于A组的62.50%(χ^2=4.013,P<0.05),治疗4周后,B组总有效率为90.00%,与A组的85.00%相当(χ^2=0.457,P>0.05);治疗2周及治疗4周后,两组患者汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分均较治疗前显著降低(P<0.05),且治疗2周后B组评分均明显低于A组(P<0.05);A组与B组不良反应发生率相当(12.50%比10.00%,χ^2=0.125,P>0.05)。结论治疗躯体形式障碍,2周后艾司西酞普兰疗效优于舍曲林,4周后艾司西酞普兰和舍曲林疗效及安全性相当,但艾司西酞普兰起效更快。 Objective To compare the clinical efficacy of escitalopram or sertraline in the treatment of somatoform disorders.Methods Totally 80 patients with somatoform disorders admitted to our hospital from January 2015 to September 2017 were selected and divided into group A and group B according to the random number table method,40 cases in each group.On the basis of psychological intervention,the patients in group A were given Sertraline Tablets and the patients in group B were given Escitalopram Tablets.Both groups were treated continuously for 4 weeks.Results After 2 weeks of treatment,the total effective rate of group B was 82.50%,which was significantly higher than 62.50% of group A(χ^2= 4.013,P<0.05).After 4 weeks of treatment,the total effective rate of group B was 90.00%,which was similar to 85.00% of group A(χ^2=0.457,P > 0.05).After 2,4 weeks of treatment,the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in the two groups were significantly lower than those before treatment P<0.05),and the scores in group B were significantly lower than those in group A after 2 weeks of treatment (P<0.05).The total incidence of adverse reactions in group A was similar to that in group B(12.50% vs.10.00%,χ^2= 0.125,P > 0.05).Conclusion Escitalopram is more effective than sertraline in the treatment of somatoform disorders after 2 weeks of treatment.Escitalopram and sertraline have similar efficacy and safety after 4 weeks of treatment,but escitalopram works faster.

关 键 词： 躯体形式障碍 艾司西酞普兰 舍曲林 临床疗效

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