作　　者： ; ; ; ; ;

机构地区： 深圳市第二人民医院

出　　处： 《临床误诊误治》 2019年第5期58-61,共4页

摘　　要： 目的探讨二甲双胍联合复方醋酸环丙孕酮治疗多囊卵巢综合征对胰岛素抵抗及性激素的影响。方法选取多囊卵巢综合征96例,采用随机数字表法随机将其分为观察组48例与对照组48例,观察组采用二甲双胍联合复方醋酸环丙孕酮进行治疗,对照组采用复方醋酸环丙孕酮进行治疗。两组均治疗6个月。检测比较两组治疗前后空腹血糖(FBG)、空腹胰岛素水平(FINS)、胰岛素抵抗指数(HOMA-IR)及卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2)、睾酮(T)水平,记录比较两组治疗期间不良反应发生情况。结果治疗前,两组FBG、FINS、HOMA-IR及FSH、LH、E_2、T水平比较差异均无统计学意义(P>0.05)。治疗后,观察组FBG、FINS、HOMA-IR及FSH、LH、T水平均较治疗前明显降低,对照组FSH、LH及T水平均较治疗前降低,差异有统计学意义(P<0.05)。治疗后,观察组FBG、FINS、HOMA-IR及FSH、LH、T水平均低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论二甲双胍联合复方醋酸环丙孕酮治疗多囊卵巢综合征能够显著改善患者胰岛素抵抗及性激素水平。 ObjectiveTo investigate the effect of metformin combined with compound cyproterone acetate on insulin resistance and sex hormones in patients with polycystic ovary syndrome (PCOS). MethodsNinety-six patients with PCOS were randomly divided into observation group (n=48) and control group (n=48) according to random number table. The observation group was treated with metformin combined with compound cyproterone acetate, while the control group was treated with compound cyproterone acetate.Both groups were treated for 6 months. The levels of fasting blood glucose (FBG), fasting insulin (FINS), HOMA insulin resistance index (HOMA-IR), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2) and testosterone (T) were measured and compared between the two groups. Adverse reactions in both groups during the treatment period were recorded and compared. ResultsBefore treatment, there was no significant difference in the levels of FBG, FINS and HOMA-IR as well as in FSH, LH, E 2 and T between the two groups ( P >0.05). After treatment, FBG, FINS, HOMA-IR, FSH, LH, and T in the observation group were significantly lower than those before treatment, and FSH, LH and T levels were lower than those before treatment, suggesting significant differences ( P <0.05). After treatment, the levels of FBG, FINS, HOMA-IR, FSH, LH and T in the observation group were lower than those in the control group, and the difference was statistically significant ( P <0.05). There was no significant difference in the incidence of adverse reactions during the treatment between the two groups ( P >0.05). ConclusionMetformin combined with compound cyproterone acetate can significantly improve insulin resistance and sex hormone levels in patients with PCOS.

关 键 词： 二甲双胍 乙酸环丙孕酮 多囊卵巢综合征 胰岛素抵抗 性激素

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