作　　者： ; ; ; ; ;

机构地区： 中山大学附属第三医院

出　　处： 《今日药学》 2017年第1期20-23,共4页

摘　　要： 目的考察在内水相加入海藻酸钠(Sa),外水相加入氯化钙(CaCl_2),对SPG膜乳化法制备聚乙二醇-聚乳酸聚乙醇酸(PEG-PLGA)微球的载药释药特性的影响。方法扫描电镜观察微球内外形态,并计算其结构参数;激光共聚焦显微镜观察药物在微球内部的分布情况;并考察微球的包封率及体外释药行为。结果加入海藻酸钠和氯化钙制得的复合微球孔隙率低,蛋白分布广,并具有较高的包封率,前期释放低,释放无迟滞。结论 PEG-PLGA复合微球载药释药性能较好,释药符合缓释制剂标准。 OBJECTIVE To investigate the influences of adding sodium alginate to the inner aqueous phase and CaCl2 to the outer aqueous phase on the physical and drug release properties of protein loaded PEG-PLGA microspheres prepared by SPG membrane emulsification. METHODS Surface and sectional morphology were analyzed by scanning electron microscopy and drug distribution was studied by confocal laser scanning microscopy. The encapsulated efficiency and release properties were also accessed. RESULTS Addition of alginate and CaCl2 resulted in higher EE,lower porosity,and increased in homogeneity of drug distribution. Moreover,it showed a suitable protein release profile without lag phase. CONCLUSION The result shows that PEG-PLGA composite microspheres are of better drug-loading and release properties.

关 键 词： 缓释微球 聚乙二醇 聚乳酸聚乙醇酸 蛋白药物 海藻酸钠 膜乳化法

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