作　　者： ; ; ; ; ;

机构地区： 广州市第一人民医院

出　　处： 《临床医学》 2017年第9期4-5,共2页

摘　　要： 目的对比分析不同梅毒检测方法的应用以及效果评价。方法随机抽取110例梅毒患者作为研究对象,将其作为评价组;将同时期收治的110例非梅毒患者设为对照组;采取化学发光法、梅毒苯胺红不加热血清反应素试验(TRUST)、梅毒螺旋体明胶凝集实验(TPPA)和金标测试法对两组患者进行检验,并比较两组患者检验后的阳性率、特异性、灵敏度和对照组中出现的假阳性情况。结果评价组中化学发光法、TRUST、TPPA和金标测试法的阳性检出例数分别为98例、94例、104例和105例,阳性率分别为89.09%、85.45%、94.55%和95.45%;TPPA的假阳性率与化学发光法、TRUST和金标测试法的假阳性率比较差异具有统计学意义(P<0.05);TRUST的特异性和灵敏度均低于化学发光法、TPPA和金标测试法,组间差异具有统计学意义(P<0.05)。结论化学发光法、TRUST、TPPA和金标测试法四种检测方式相比之下,TPPA法比较适合用作检验梅毒螺旋抗体,因其阳性检出率、特异性和灵敏度较高,假阳性率不明显,综合效果甚佳。 Objective To evaluate the application of different testing for syphilis. Methods A total of 110 patients with syphilis were randomly selected as the evaluation group,and 110 cases of non-syphilitic in the same period were selected as the control group. All of them were taken the testing of chemiluminescence,toluidine red unheated serum reagin test（ TRUST）,Treponema pallidum particle agglutination test（ TPPA） and the gold standard. The rates of positive,specificity,sensitivity of both groups and the rates of false positive in the control group were compared. Results The cases tested by TRUST,chemiluminescence,TPPA and gold test,positive cases were respectively 98 cases（ 89. 09%）,94 cases（ 85. 45%）,104 cases（ 94. 55%） and 105 cases（ 95. 45%） in group of evaluation. The false positive rate by TPPA was lower than TRUST,chemiluminescence and gold test,and there was significant difference（ P〈0. 05）. The specificity and sensitivity of TRUST was lower than that of chemiluminescence,TPPA and the gold standard test,there was significant difference between groups（ P〈0. 05）. Conclusions TPPA for syphilis antibody test have a higher rate of detection,higher specificity and sensitivity,lower rate of false positive. It is more suitable for syphilis antibody test.

关 键 词： 梅毒 检测方法 效果 阳性率

领　　域： []