作　　者： ; ; ;

机构地区： 海南省三亚市人民医院

出　　处： 《中国医药导报》 2019年第23期131-134,共4页

摘　　要： 目的研究血清白细胞介素-1β(IL-1β)、基质Gla蛋白(MGP)水平与维持性血液透析(MHD)患者心脏瓣膜钙化(CVC)的关系。方法选择2016年1月~2018年11月在海南省三亚市人民医院接受MHD治疗的80例患者为研究对象,记为观察组。根据患者是否发生CVC,分为CVC组(n=37)和非CVC组(n=43)。另选同期接受健康体检的志愿者80名作为对照组。统计比较各组的临床资料,分析患者IL-1β、MGP与年龄和透析龄的相关性,通过Logistic回归分析法计算MHD患者CVC的影响因素。结果观察组的CVC比例、IL-1β水平高于对照组,而MGP水平低于对照组(P<0.01)。CVC组的年龄、透析龄及IL-1β水平高于非CVC组,而MGP水平低于非CVC组(P<0.05或P<0.01)。Pearson相关性分析发现,IL-1β与年龄及透析龄均呈正相关(r=0.614、0.679,均P<0.05),而MGP与年龄及透析龄均呈负相关(r=-0.702、-0.715,均P<0.05)。Logistic回归分析结果显示,IL-1β≥160 pg/mL(OR=1.244,95%CI:1.021~4.820,P<0.01)、透析龄≥30个月(OR=1.319,95%CI:1.039~10.512,P<0.05)及MGP<2.55 ng/mL(OR=1.108,95%CI:1.007~11.287,P<0.01)均为MHD患者CVC的危险因素。结论血清IL-1β及MGP水平与MHD患者CVC密切相关,且二者与透析龄均为患者并发CVC的影响因素,临床上可通过监测此类指标,更好地评估患者的病情。 Objective To study the relationship between serum level of interleukin-1β(IL-1β),matrix Gla protein(MGP)and cardiac valve calcification(CVC)in maintenance hemodialysis(MHD)patients.Methods Eighty patients who received MHD treatment in Sanya People′s Hospital of Hainan Province from January 2016 to November 2018 were selected as the study subjects and recorded as the observation group.Patients were divided into CVC group(n=37)and non-CVC group(n=43)according to whether they had CVC or not.Another 80 volunteers who received health examination during the same period were selected as the control group.The clinical data of the two groups was counted and compared.The clinical data of the subgroup in observation group was analyzed.The correlation between IL-1β,MGP and age,dialysis age was analyzed.The influencing factor of CVC in MHD patients were calculated by Logistic regression analysis.Results The ratio of CVC and the level of IL-1βin the observation group were higher those that in the control group,while the level of MGP was lower than that in the control group(P<0.01).Age,dialysis age and IL-1βlevel in CVC group were higher than those in non-CVC group,while MGP level was lower than that in non-CVC group(P<0.05 or P<0.01).Pearson analysis showed that,IL-1βwas positively correlated with age and dialysis age(r=0.614,0.679,all P<0.05),while MGP was negatively correlated with age and dialysis age(r=-0.702,-0.715,all P<0.05).Logistic regression analysis showed that,IL-1β≥160 pg/mL(OR=1.244,95%CI:1.021-4.820,P<0.01),dialysis age≥30 months(OR=1.319,95%CI:1.039-10.512,P<0.05)and MGP<2.55 ng/mL(OR=1.108,95%CI:1.007-11.287,P<0.01)were risk factors for CVC in MHD patients.Conclusion Serum levels of IL-1βand MGP are closely related to CVC in MHD patients,and both of them and dialysis age are the influencing factors of CVC in MHD patients.Clinical monitoring of these indicator can better assess patient′s condition.

关 键 词： 血清白细胞介素 基质 蛋白 维持性血液透析 心脏瓣膜钙化 关系

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