作　　者： ; ; ;

机构地区： 南方医科大学

出　　处： 《中国临床研究》 2019年第8期1063-1065,共3页

摘　　要： 目的探讨雄激素介导的自噬抑制对痤疮患者皮脂分泌的影响。方法选取2016年9月至2018年9月皮肤性病科收治的患有痤疮的女性患者共68例为观察组,行抗雄激素(炔雌醇环丙孕酮片)治疗3个月。另随机选取68名无痤疮的正常女性志愿者作对照组。检测对照组和观察组治疗前后的血清雄激素双氢睾酮(DHT)、皮脂分泌甘油三酯(TG)水平,以及用Western blot法检测自噬标志性蛋白LC3-Ⅱ和P62的含量,并进行比较。结果观察组治疗前DHT水平高于对照组,治疗后DHT水平较治疗前下降,且低于对照组(P<0.01);观察组治疗前皮脂分泌TG水平高于对照组,治疗后TG水平较治疗前下降(P<0.01),接近对照组TG水平(P>0.05);观察组治疗前LC3-Ⅱ、P62含量低于对照组,治疗后LC3-Ⅱ、P62含量较治疗前升高,且高于对照组(P<0.01)。结论雄激素介导的自噬抑制对皮脂分泌有促进作用,通过抑制雄激素的分泌,可以解除一定程度的自噬抑制,减少皮脂的异常分泌。 Objective To investigate the effect of androgen-mediated autophagy on sebum secretion in acne patients. Methods A total of 68 female acne patients who received anti-androgen treatment (ethinylestradiol and cyproterone acetate tablets,3 months) from September 2016 to September 2018 were selected as observation group,and 68 normal female volunteers without acne were randomly selected as control group.The levels of serum dihydrotestosterone (DHT), sebum triglyceride (TG) and autophagy marker protein LC3-Ⅱ and P62 (by Western blot) were detected and compared in the observation group (before and after treatment) and the control group.Results The serum DHT and sebum TG level in the observation group before treatment were higher than those in the control group (P < 0.01).After treatment,serum DHT and sebum TG level decreased in observation group,and DHT level was lower than those in the control group (P < 0.01) and sebum TG level was close to that in control group (P > 0.05).The contents of LC3-Ⅱ and P62 in the observation group before treatment were lower than those in the control group,and the contents of LC3-Ⅱ and P62 after treatment were higher than those before treatment,and higher than those in the control group (P < 0.01 ).Conclusion Androgenmediated autophagy inhibition can promote sebum secretion.Through inhibiting androgen secretion,it can eliminate certain degree of autophagy inhibition and reduce abnormal sebum secretion.

关 键 词： 痤疮 皮脂分泌 雄激素 自噬抑制 双氢睾酮 甘油三酯 蛋白 蛋白

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