作　　者： ;

机构地区： 华南师范大学物理与电信工程学院

出　　处： 《激光生物学报》 2019年第6期523-528,共6页

摘　　要： 近年来,许多研究人员不断努力为药物、除草剂、食品添加剂等小分子物质高特异性、高灵敏的检测和分析开发新的方法和技术。然而,目前通用的分子检测方法的实施需要较长的前处理时间、昂贵的大型仪器设备及专业操作人员,无法实现有选择的识别及快速的现场检测。所以,在本研究中我们将量子点表面分子印迹聚合物(QDs@MIPs)与光纤相结合,构建了一种新的光纤探头,并将该光纤探头应用于光纤传感器,检测小分子物质莱克多巴胺(RAC)。试验中,我们对QDs@MIPs的表征、光纤探头的性能、光纤探头对RAC的浓度响应、光纤传感器的特异性及光强分布进行了探究。研究结果表明,该光纤探头应用于光纤传感器能够提高光纤传感器的灵敏度,使分子印迹光纤传感器具有更高的特异性识别能力和较强的抗干扰能力,同时检测过程简便快捷,适用于快速的现场检测。 Specific and sensitive detection of small molecules such as drugs,herbicides,food additives etc.has been widely studied.However,most of the commonly used analytical methods lack high specificity and their utilization is hindered due to the complex procedures,expensive detection instruments and the need of highly skilled personnel.In this study,we combined quantum dots surface molecular imprinting polymers(QDs@MIPs)with optical fiber and constructed a novel optical fiber sensor for the detection of small molecule ractopamine(RAC).In the experiment,we explored the characterization of QDs@MIPs,the performance of optical fiber probes,the concentration response of optical fiber probes to RAC,the specificity and the intensity distribution of the optical fiber sensors.Results showed that the optical fiber probes could improve the sensitivity of the fiber sensor.The novel molecular imprinted optical fiber sensors have higher specific recognition ability,selective adsorption capabilities and strong anti-interference ability.Meanwhile,this detection method is suitable for point-of-care application due to the simple and fast detection process.

关 键 词： 量子点 分子印迹聚合物 光纤传感器 分子检测 特异性识别

领　　域： []