作　　者： ; ;

机构地区： 广州市增城区人民医院内分泌科广东广州511300

出　　处： 《现代医学》 2018年第8期863-866,共4页

摘　　要： 目的:探讨1型糖尿病(T1DM)患者血清B细胞活化因子(BAFF)水平的变化及其临床意义。方法:采用酶联免疫吸附法(ELISA)检测26例T1DM患者、25例2型糖尿病(T2DM)患者、20例健康体检者血清BAFF水平。比较三组间差异,探讨血清BAFF与患者年龄、病程、胰岛功能、糖化血红蛋白、血脂等的关系。结果:血清BAFF水平T1DM组高于T2DM组及对照组(297. 54 vs. 218. 80 vs. 199. 20,F=4. 257,P <0. 05);T2DM组与对照组则差异无统计学意义(P> 0. 05); T1DM组血清BAFF水平与糖化血红蛋白(HbA1c)呈正相关(r=0. 613,P=0. 001),与空腹C肽(FCP)呈负相关(r=-0. 506,P=0. 008); T1DM组血清BAFF水平与总胆固醇(TC)、甘油三酯(TG)呈正相关(r=0. 413,0. 581,P=0. 036,0. 002);多元逐步法回归分析得出的回归方程为:FCP=0. 494-0. 001×BAFF水平;其中R2=0. 256,F=8. 241,P=0. 008。此方程表明BAFF水平与FCP呈弱负相关。结论:BAFF水平可能与T1DM患者血糖升高、C肽下降密切相关,并BAFF水平可能与T1DM患者血脂紊乱相关。 Objective： To investigate the serum level and clinical significance of B cell-activating factor belonging to the TNF family（ BAFF） in patients with type 1 diabetes mellitus（ T1 DM）. Methods： 26 T1 DM patients,25 T2 DM patients and 20 healthy subjects were enrolled in our study. Serum BAFF were tested with emzyme-linked immunosorbent assay（ ELISA）. The differences between the three groups were compared to discuss the relationship between serum BAFF and age,course of disease,islet function,glycosylated hemoglobin,blood lipids and so on.Results： Serum BAFF level in T1 DM group were higher than that in T2 DM group and the control group（ 297. 54 vs218. 80 vs 199. 20,F = 4. 257,P〈0. 05）. Serum BAFF level in T2 DM group was higher than that of the control group（ P〈0. 05）; 2. In T1 DM group,the serum BAFF level were positively correlated with HbA1 c（ r =-0. 506,P = 0. 008） while negatively correlated with FCP（ r =-0. 506,P = 0. 008）; serum BAFF level were positively correlated with TC and TG（ r =-0. 413,0. 581,P = 0. 036,0. 002）; 3. The regression equation of multivariate stepwise regression analysis was as follow： FCP = 0. 494-0. 001 × BAFF; R^2= 0. 256,F = 8. 241,P = 0. 008. This equation showed that the serum BAFF level were negatively correlated with FCP. Conclusion： Serum BAFF level may be closely related with elevated blood glucose and decreasing C-peptide in T1 DM patients,which may be associated with dyslipidemia in T1 DM patients.

关 键 词： 型糖尿病 细胞活化因子 胰岛功能

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