作　　者： ; ;

机构地区： 南方医科大学珠江医院

出　　处： 《当代医药论丛》 2020年第4期18-20,共3页

摘　　要： 在采用传统的给药方式(如口服给药、静脉注射给药等)对患者进行药物治疗的过程中,其体内的药物浓度易出现较大幅度的波动,且需要频繁多次为其给药。采用这种给药方式一方面会使患者的治疗效果大打折扣,易导致其出现不良反应,另一方面还需要设计出多种药物剂型。因此,如何制备出具有理想药物缓释性能的药物载体是临床医学和制药学领域重要的研究课题。药物缓释系统(Drug delivery system,DDS)是近年来医疗领域研究的热点。水凝胶是药物缓释系统最主要的载体之一。水凝胶具有良好的生物相容性,能适应人体内的不同环境。本文主要是介绍将水凝胶作为药物缓释载体的最新研究进展。 In the process of drug treatment for patients with traditional drug administration methods(such as oral administration,intravenous administration,etc.),the drug concentration in their bodies is prone to large fluctuations,and it needs to be administered frequently for many times.On the one hand,this method of drug administration will greatly reduce the therapeutic effect of patients and easily lead to adverse reactions.On the other hand,it is also necessary to design a variety of drug dosage forms.Therefore,how to prepare the drug carrier with the ideal drug sustained release properties is an important research topic in the field of clinical medicine and pharmacy.Drug delivery system(DDS)is a hot topic in recent years.Hydrogel is one of the most important carriers of drug sustained release system.Hydrogels have good biocompatibility and can adapt to different environments in human body.This paper mainly introduces the latest research progress of hydrogels as sustained drug release carriers.

关 键 词： 水凝胶 药物缓释系统 药物载体 席夫碱反应 波聚合 自修复

领　　域： []