作　　者： ; ;

机构地区： 中国科学院深圳先进技术研究院生物医学与健康工程研究所

出　　处： 《集成技术》 2020年第1期1-11,共11页

摘　　要： 脑胶质瘤是严重危害人类健康的重大脑疾病。脑胶质瘤的早诊断、早治疗对于改善脑胶质瘤患者生存期起着至关重要的作用。当前,脑胶质瘤的诊断主要依靠磁共振、计算机断层扫描等大型仪器设备,难以精准识别脑胶质瘤边界、术中实时引导手术治疗;且化疗药物受血脑屏障的限制,药物到达病灶浓度极低,难以达到良好的治疗效果,且还具有严重的副作用。近年来,纳米技术的飞速发展为脑胶质瘤的精准诊疗带来了新希望。新型功能化纳米探针具有高灵敏、高特异、多功能的优势,已被成功用于脑胶质瘤的多模态诊断和治疗研究,并取得了重要研究进展。该文先介绍了国内外研究小组利用功能化纳米探针开展脑胶质瘤精准诊断和治疗的研究进展;然后,重点介绍了纳米探针跨血脑屏障、多模态成像显影脑胶质瘤边界及成像引导脑胶质瘤精准治疗三方面的研究工作,评述了纳米探针制备、表面功能化修饰,以及用于脑胶质瘤成像和治疗过程中面临的难题;最后,对功能化纳米探针在走向临床应用过程中面临的机遇和挑战进行了展望。 Glioma is a serious brain disease that seriously endangers human health.Early diagnosis and therapy of glioma play a vital role in improving the survival of glioma patients.Currently,the diagnosis of brain glioma mainly relies on advanced instruments such as magnetic resonance imaging and computed tomography,which is difficult to accurately identify the margin of brain tumor and guide intraoperative surgical resection of the lesion.Moreover,due to the limitation of blood-brain barrier,the concentration of drugs into the brain tissue is very low,which is difficult to achieve good therapeutic effect and has serious side effects.In recent years,the rapid development of nanotechnology has brought new hope for accurate diagnosis and therapy of glioma.With the advantages of high sensitivity,high specificity and multifunction,the new functional nanoprobe has been successfully applied in the research of multimodality diagnosis and treatment of glioma.This article mainly introduces the recent advances of nanoprobe for precise diagnosis and treatment of glioma,focusing on the nanoprobes passing through the blood-brain barrier,multimodality imagingguided glioma margin identification and imaging guided precision glioma treatment.The preparation and surface functionalization modification of nanoprobe,as well as for glioma imaging and treatment are further discussed.Finally,the opportunities and challenges faced by functional nanoprobes in the clinical application are prospected.

关 键 词： 脑胶质瘤 血脑屏障 纳米探针 多模态成像 光热治疗

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