作　　者： ; ;

机构地区： 南方医科大学

出　　处： 《国际检验医学杂志》 2019年第22期2729-2732,2737,共5页

摘　　要： 目的探讨抗苗勒管激素(AMH)联合内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)对多囊卵巢综合征(PCOS)的诊断价值。方法选择2018年3-9月在南方医科大学附属深圳市妇幼保健院初次就诊的237例PCOS患者作为病例组,同期的203名体检健康者为对照组。用酶联免疫吸附试验(ELISA)法测定血清Vaspin,化学发光法对2组血清行AMH、雌二醇(E2)、睾酮(Testo)、黄体生成素(LH)及卵泡刺激素(FSH)测定。采用SPSS19.0软件对2组受试者的各项指标进行统计学分析。结果病例组血清Vaspin、AMH、Testo及LH明显高于对照组(P<0.05),而2组的E2与FSH差异无统计学意义(P>0.05)。AMH、Vaspin与LH的最佳诊断临界值分别为6.29ng/mL、3.40ng/mL和6.29IU/L。AMH与Vaspin联合检测的受试者工作特征曲线下面积最大(0.917)。病例组中,AMH联合Vaspin对PCOS的检出率(81.01%)高于AMH、Vaspin、LH单独检测(67.09%、68.35%、75.52%,χ^2=15.283,P<0.01);在最佳诊断临界值时,与AMH、Vaspin、LH单独检测比较(93.06%、80.79%、61.58%),AMH与Vaspin联合诊断PCOS的特异度最高(94.58%,χ^2=100.407,P<0.01)。结论测定血清AMH和Vaspin是诊断PCOS的新方法,其联合检测可以作为PCOS的诊断指标。 Objective To explore the diagnostic value of anti-Mullerian hormone(AMH)combined with visceral fat-specific serine protease inhibitor(Vaspin)in polycystic ovary syndrome(PCOS).Methods From March to September 2018,237 patients with PCOS who were first treated in Affiliated Shenzhen Maternity and Child Healthcare Hospital of Southern Medical University were selected as the case group,and 203 healthy persons in the same period were selected as the control group.Serum Vaspin was measured by ELISA.AMH,estradiol(E2),testosterone(Testo),luteinizing hormone(LH)and follicle stimulating hormone(FSH)were measured by chemiluminescence.SPSS19.0 software was used to analyze the indicators of two groups of subjects.Results The serum levels of Vaspin,AMH,Testo and LH in the case group were significantly higher than those in the control group(P<0.05),but there was no significant difference in E2 and FSH between the two groups(P>0.05).The optimal diagnostic thresholds for AMH,Vaspin and LH were 6.29 ng/mL,3.40 ng/mL and 6.29 IU/L,respectively.The area under the working characteristic curve of subjects tested by AMH and Vaspin was the largest(0.917).In the case group,the detection rate of PCOS by AMH combined with Vaspin(81.01%)was higher than that by AMH,Vaspin and LH alone(67.09%,68.35%,75.52%,χ^2=15.283,P<0.01),compared with AMH,Vaspin and LH alone(93.06%,80.79%,61.58%)at the optimal diagnostic threshold,the specificity of AMH combined with Vaspin for PCOS was the highest(94.58%,χ^2=100.407,P<0.01).Conclusion Detection of serum AMH and Vaspin is a new method for the diagnosis of PCOS,the combined detection of AMH and Vaspin can be used as a diagnostic index for PCOS.

关 键 词： 多囊卵巢综合征 抗苗勒管激素 内脏脂肪特异性丝氨酸蛋白酶抑制剂 联合诊断

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