作　　者： (）;

机构地区： 深圳市宝安区石岩人民医院

出　　处： 《中国药物评价》 2019年第2期138-140,共3页

摘　　要： 目的:探讨丁苯酞联合阿托伐他汀对急性脑梗死患者神经功能的影响。方法:选取2017年7月至2018年6月期间我院收治的92例急性脑梗死患者,随机分为对照组和联合组,每组46例。对照组在常规治疗(溶栓、抗血小板聚集、改善循环、营养脑细胞等)基础上给予阿托伐他汀治疗,联合组在对照组基础上增加丁苯酞注射液治疗,比较两组治疗效果,并分别于用药治疗前和治疗14 d后采集静脉血,检测炎症因子IL-6、CRP水平,并对比两组不良反应发生情况。结果:联合组治疗总有效率较对照组高;治疗后,联合组NIHSS评分、IL-6及CRP水平明显低于治疗前与对照组,上述差异均具有统计学意义(P <0. 05)。联合组不良反应总发生率略高于对照组,但差异无统计学意义(P> 0. 05)。结论:丁苯酞联合阿托伐他汀治疗急性脑梗死安全有效,可明显改善患者神经功能,减轻机体炎症反应。 Objective:To investigate the influence of butyphthalide combined with atorvastatin on nerve function in patients with acute cerebral infarction.Methods:92 patients with acute cerebral infarction who admitted in the hospital from July 2017 to June 2018 were selected as the subjects.All patients were randomly divided into control group and combined group,with 46 cases in each group.Control group was given atorvastatin based on routine treatment(thrombolysis,anti-platelet aggregation,improving circulation,nourishing brain cell),while combined group was treated with butyphthalide injection based on control group.The curative effects of two groups were compared.The venous blood was taken before treatment and after treatment for 14d,the levels of IL-6 and CRP were detected,and the adverse reactions were compared between the two groups.Results:The total effective rate of combined group was higher than that of control group;After treatment,the NIHSS score,IL-6 and CRP in combined group were lower than those before treatment and control group,and the above differences were statistically significant(P<0.05).The total incidence of adverse reactions in combined group was slightly higher than that in control group,but the difference was not statistically significant(P>0.05).Conclusion:Butyphthalide combined with atorvastatin in treatment of patients with acute cerebral infarction is safe and effective,which can significantly improve nerve function and reduce inflammatory response.

关 键 词： 丁苯酞 阿托伐他汀 急性脑梗死 神经功能

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