作　　者： ; ; ;

机构地区： 江门市中心医院

出　　处： 《中国医学创新》 2019年第11期9-12,共4页

摘　　要： 目的:探讨血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和T淋巴细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)的水平变化在慢性阻塞性肺疾病(COPD)急性加重期和缓解期中的临床价值研究。方法:对75例COPD患者急性期和缓解期血清中的TNF-α、IL-6、IL-1β和CD4^+、CD8^+水平进行检测,同时选择健康体检中心的健康老年人30例作为对照组。分别行肺功能检测,对血清TNF-α、IL-6、IL-1β和CD4^+、CD8^+与肺功能指标(FEV1%pred、FEV1/FVC%)进行相关性分析。结果:COPD缓解期患者的FEV1%pred、FEV1/FVC%均较COPD急性期明显提高,但均比对照组低,差异均有统计学意义(P<0.05)。COPD缓解期患者血清中TNF-α、IL-6和IL-1β的水平均较急性期时明显下降,但均比对照组高,差异均有统计学意义(P<0.05);COPD缓解期患者血清中CD4^+、CD4^+/CD8^+均较急性期时明显升高,但均比对照组低,差异均有统计学意义(P<0.05);COPD缓解期患者血清中CD8^+较急性期时降低,但仍比对照组高,差异有统计学意义(P<0.05)。COPD患者血清TNF-α、IL-6、IL-1β及CD8^+百分比与肺功能指标中的FEV1%pred、FEV1/FVC%均呈负相关(P<0.05);CD4^+百分比、CD4^+/CD8^+与肺功能指标中的FEV1%pred、FEV1/FVC%均呈正相关(P<0.05)。结论:血清TNF-α、IL-6、IL-1β和CD4^+、CD8^+均参与了COPD的发生发展,并与肺功能相关联,为判断患者病情严重程度、治疗效果及预后提供一定的依据。 Objective:To investigate the serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6), interleukin-1β(IL-1β)and T lymphocyte subsets(CD4^+,CD8^+,CD4^+/CD8^+)levels of clinical value in the acute exacerbation and stable phase of chronic obstructive pulmonary disease(COPD).Method:The levels of TNF-α,IL-6,IL-1β,CD4^+ and CD8^+ in serum of 75 patients with COPD were detected in the acute phase and remission phase.30 healthy elderly people in the health check-up center were selected as the control group.Pulmonary function tests(FEV1%pred,FEV1/FVC%)were performed to analyze the correlation between serum TNF-α,IL-6,IL-1β,CD4^+,CD8^+ and lung function indexes.Result:FEV1%pred,FEV1/FVC% in patients with COPD remission were significantly higher than those in the acute phase of COPD,but lower than those in the control group,with statistically significant differences(P<0.05).Serum levels of TNF-α,IL-6 and IL-1βin patients with COPD remission were significantly lower than those in the acute phase,but higher than those in the control group,with statistically significant differences(P<0.05).CD4^+ and CD4^+/CD8^+ in the serum of patients with COPD remission were significantly higher than those in the acute phase,but lower than those in the control group,with statistically significant differences(P<0.05).The serum CD8^+ in COPD remission patients was lower than that in the acute phase,but still higher than that in the control group,with statistically significant difference(P<0.05).The percentages of serum TNF-α,IL-6,IL-1β and CD8^+ in COPD patients were negatively correlated with FEV1%pred and FEV1/FVC% in lung function indexes(P<0.05).The percentage of CD4^+,CD4^+/CD8^+ were positively correlated with FEV1%pred and FEV1/FVC% in lung function indexes(P<0.05).Conclusion:Serum TNF-α,IL-6,IL-1β,CD4^+ and CD8^+ are involved in the development of COPD and are associated with pulmonary function,which provides a basis for judging the severity,treatment and prognosis of patients.

关 键 词： 慢性阻塞性肺疾病 细胞因子 肿瘤坏死因子 白介素

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