作　　者： ; ;

机构地区： 佛山市中医院

出　　处： 《中医临床研究》 2019年第3期41-43,共3页

摘　　要： 目的:探究慎柔养真汤联合甲钴胺治疗糖尿病性便秘及其对P物质及血管活性肠肽的影响。方法:选择我院收治的糖尿病性便秘患者64例,随机分为两组,各32例,对照组患者予甲钴胺注射液0.5 mg肌注,每周3次;试验组在对照组的基础上加服慎柔养真汤浓煎剂,分2次服,日1剂。两组均以8周为1个疗程,共治疗1个疗程。治疗结束后对比分析两组临床疗效、P物质及血管活性肠肽及不良反应发生情况。结果:与治疗前相比,治疗后两组大便燥结程度、排便费力程度、脘腹胀满及排便时间间隔等证候评分降低,血浆血管活性肠肽水平均降低,P物质水平升高;与对照组相比,试验组总有效率较高,证候评分以及血浆血管活性肠肽水平较低,P物质水平较高(P <0.05),两组不良反应发生率相比无显著差异(P> 0.05)。结论:慎柔养真汤联合甲钴胺治疗糖尿病性便秘患者临床疗效显著,能显著缓解临床症状,提高P物质水平,抑制血管活性肠肽水平,安全有效。 Objective: To explore the effect of Shenrou Yangzhen Decoction combined with mecobalamine on the treatment of diabetic constipation and its effect on substance P and vasoactive intestinal peptide. Methods: Sixty-four diabetic constipation patients admitted to our hospital were selected and randomly divided into two groups, with 32 patients in each group. The control group was given 0.5 mg myocardial injection, 3 times a week. On the basis of the treatment of the control group, the experimental group received Shenrou Yangzhen decoction, thick decoction in 2 times, 1 dose per day. Each group received one course of treatment for 8 weeks, and one course of treatment in total. After the treatment, the clinical efficacy, substance P, vasoactive intestinal peptide and adverse reactions of the two groups were compared and analyzed. Results: Compared with before treatment, the scores of syndromes of the two groups after treatment were reduced, such as degree of fecal dryness, degree of defecation exertion, abdominal distension and time interval of defecation, plasma vasoactive intestinal peptide level was decreased, and substance P level was increased. Compared with the control group, the experimental group had higher overall efficiency, lower syndrome scores and plasma vasoactive intestinal peptide levels, higher substance P (P<0.05), and there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Shenrou Yangzhen Decoction combined with mecobalamine had significant effect on the treatment of diabetic constipation, it could significantly relieve the clinical symptoms, improve the level of substance P, and inhibit the level of vasoactive intestinal peptide, which was safe and effective.

关 键 词： 慎柔养真汤 甲钴胺 糖尿病性便秘 物质 血管活性肠肽

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