作　　者： ; ; ;

机构地区： 南方医科大学珠江医院

出　　处： 《实用医学杂志》 2019年第9期1458-1461,共4页

摘　　要： 目的研究NMDA受体在抗NMDA受体脑炎患者卵巢畸胎瘤组织中的表达特点,进一步探讨其与抗NMDA受体脑炎疾病发生的关系。方法收集2014年7月至2018年7月南方医科大学珠江医院收治的8例抗NMDA受体脑炎患者的卵巢畸胎瘤组织作为研究对象,选择同期不合并脑炎患者的畸胎瘤组织40例(有神经组织者20例、无神经组织者20例)和正常卵巢组织20例作为对照组,采用免疫组织化学染色法检测NMDA受体在各组卵巢组织中的表达情况,分析其与抗NMDA受体脑炎的关系。结果 NMDA受体主要表达于卵巢畸胎瘤细胞浆中,绝大部分表达于卵巢畸胎瘤组织中的鳞状上皮组织,其中基底层细胞表达量最高。NMDA受体在合并抗NMDA受体脑炎的卵巢畸胎瘤组织中的表达率及表达量均明显高于非脑炎卵巢畸胎瘤组织及正常组织(P <0.05)。结论卵巢畸胎瘤组织中NMDA受体的高表达可能参与了抗NMDA受体脑炎的发生发展。 Objective To assess the expression of N-methyl-D-aspartate(NMDA)receptor in the ovarian teratoma tissue of patients complicated with anti-NMDA receptor encephalitis. To analysis the correlation between anti-NMDAR encephalitis and NMDA receptor in the ovarian teratoma. Methods All cases were obtained from July 2014 to July 2018 at Zhujiang Hospital of Southern Medical University,including 8 ovarian teratoma tissues with anti-NMDA receptor encephalitis,40 ovarian teratoma tissues without encephalitis( half of them contain nerve tissue) and 20 normal ovarian tissues. Results The NMDA receptor were mainly expressed in the cytoplasm of ovarian teratoma,especially in the squamous epithelial tissue. The closer to the basal layer tissue,the higher the expression intensity. The positive rate of NMDA receptor in teratoma with anti-NMDA receptor encephalitis was higher than that of simple ovarian teratoma and normal ovarian tissue. Conclusion High expression of NMDA receptor in ovarian teratoma tissues may be involved in the development of anti-NMDA receptor encephalitis.

关 键 词： 卵巢畸胎瘤 抗 甲基 天冬氨酸受体脑炎 抗体 免疫组织化学

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