作　　者： ; ;

机构地区： 韶关学院医学院

出　　处： 《现代预防医学》 2018年第14期2666-2671,共6页

摘　　要： 目的探讨脂蛋白脂酶(LPL)基因S447X多态性与糖尿病(DM)易感性之间的关联。方法检索Pub Med、OvidSP、CBM、中国知网和万方数据,收集关于LPL S447X多态性与DM的病例-对照研究,2名评价者按筛选标准分析文献,提取资料,质量评价,并完成Meta分析和试验序贯分析(TSA)。结果 9篇文献被纳入Meta分析,2型DM(T2DM)患者G等位基因(OR=0.66,95%CI为0.48~0.90,P=0.01)和CG基因型(OR=0.63,95%CI为0.43~0.91,P=0.02)频率比对照组降低。TSA结果显示显性模型的累积Z值跨越传统界值线、TSA界值线和RIS线。与CC基因型相比,CG+GG基因型DM患者TG、TC和LDL-C水平降低,而HDL-C水平升高。结论 LPL基因S447X多态性G等位基因和CG基因型是T2DM的保护因素,可改善脂代谢异常而降低T2DM的患病风险。 Objective To investigate the relationship between S447 X polymorphism of lipoprotein lipase（LPL） gene and diabetes mellitus（DM）. Methods Databases including Pub Med, Ovid SP, CBM, CNKI and Wanfang were searched to collect all case-control studies on the association between LPL S447 X polymorphism and DM. According to the selection criteria, 2 reviewers screened the literatures, extracted data, evaluated the quality, and performed Meta-analysis and trial sequential analysis（TSA）. Results Nine studies were collected into Meta-analysis. The frequencies of G allele（OR=0.66, 95%CI 0.48-0.90, P=0.01） and CG genotype（OR=0.63, 95%CI 0.43-0.91, P=0.02） in type 2 DM（T2 DM） patients were significantly lower than those in the control group. TSA showed that the cumulative Z values of dominant model had already crossed the traditional boundary line, TSA threshold value line and RIS line. Compared with CC genotype, TG TC and LDL-C levels were decreased and HDL-C levels were increased in CG ＋GG genotype DM patients. Conclusion The G allele and CG genotype of LPL gene S447 X polymorphism are protective factors for T2 DM. The CG ＋GG genotype can improve the abnormalities of lipid metabolism and reduce the risk of T2 DM.

关 键 词： 脂蛋白脂酶 多态性 基因 糖尿病 分析 试验序贯分析

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