作　　者： ; ;

机构地区： 广州中医药大学第一临床医学院

出　　处： 《广州中医药大学学报》 2019年第12期1896-1900,共5页

摘　　要： 【目的】探讨解毒化湿方治疗普通型登革热的疗效及安全性。【方法】将125例普通登革热患者随机分为西医组62例和中医组63例。西医组患者给予西医常规治疗,中医组患者在西医组西医常规治疗基础上联合使用解毒化湿方治疗,疗程为7 d。比较2组患者的平均退热时间、平均住院时间和平均总病程,以及治疗前后白细胞、血小板计数和凝血功能[凝血时间(PT)、活化部分凝血酶时间(APTT)]的变化情况,观察2组患者的不良反应事件发生情况。【结果】(1)中医组的平均退热时间、平均住院时间和平均总病程分别为89 h、121 h和144 h,西医组分别为134 h、168 h和196 h,组间比较,中医组的平均退热时间、平均住院时间和平均总病程均较西医组明显缩短,差异均有统计学意义(P<0.001)。(2)治疗后,2组患者白细胞、血小板水平均较治疗前有一定程度升高,PT、APTT水平均较治疗前有一定程度改善,差异均有统计学意义(P<0.05);但治疗后组间比较,差异均无统计学意义(P>0.05)。(3)研究过程中,2组患者均无明显不良反应事件发生。【结论】在对症治疗基础上联合使用解毒化湿方治疗普通型登革热具有较好疗效,不但能显著缩短退热时间、住院时间及总病程,还对患者的白细胞和血小板水平及凝血功能有一定程度的改善作用。 Objective To evaluate the efficacy and safety of Jiedu Huashi Decoction(JDHSD)in the treatment of common dengue fever. Methods A total of 125 cases of common dengue fever patients were randomized into western medicine group(62 cases)and Chinese medicine group(63 cases),which were treated by conventional western medicine,JDHSD combined with conventional western medicine respectively. The treatment for the two groups covered 7 days. The primary outcomes included mean antipyretic time,mean hospitalization time,and mean disease course. The secondary outcomes covered white blood cell count, platelet count and coagulation function indicators of prothrombin time(PT)and activated partial thromboplastin time(APTT). The incidence of adverse events was considered as the safety indicator. Results(1) The mean antipyretic time, mean hospitalization time,and mean disease course in Chinese medicine group were 89 h,121 h,144 h,and those in western medicine group were 134 h,168 h,196 h,respectively. The inter-group comparison showed that the mean antipyretic time, mean hospitalization time, and mean disease course in Chinese medicine group were shorter than those in western medicine group, and the difference was statistically significant(P<0.001).(2)After treatment,white blood cell count and platelet count in the two groups were increased,and PT and APTT were improved compared with those before treatment, the difference being statistically significant(P<0.05).However,the differences of PT and APTT between the two groups after treatment were insignificant(P > 0.05).(3) During the trial, no adverse event occurred in both groups. Conclusion On the basis of symptomatic treatment, JDHSD exerts certain effect for the treatment of common dengue fever by shortening the antipyretic time, hospitalization time, and disease course, and by improving white blood cell count, platelet count and coagulation function indicators.

关 键 词： 解毒化湿方 中医药疗法 登革热 临床观察

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