作　　者： ; ; ; ;

机构地区： 中山市中智药业集团有限公司广东中山528437

出　　处： 《中医肿瘤学杂志》 2019年第2期33-36,共4页

摘　　要： 目的:开展红参破壁饮片与其传统饮片的抗疲劳、耐缺氧和耐低温的药理药效作用比较以及急性毒性作用比较研究,探索两种形式饮片的量效关系和量毒关系,为红参破壁饮片的安全、有效应用提供基础科学依据。方法:采用小鼠负重游泳、小鼠常压耐缺氧、耐低温试验比较分析红参破壁饮片与其传统饮片的药理药效差异;采用最大给药量法(MTD)观察红参破壁饮片及其传统饮片的毒性反应差异。结果:同等剂量的红参破壁饮片耐缺氧、抗疲劳和耐低温的作用比其传统饮片更显著(P<0.05);传统饮片1/2剂量的破壁饮片具有与其同等的药理药效作用;以最大给药量法对小鼠灌胃给药红参破壁饮片(剂量相当于其传统饮片临床用量的7~21倍),未出现急性毒性反应。结论:红参传统饮片制备成破壁饮片后,降低剂量应用,具有与传统饮片一致的抗疲劳、耐缺氧和耐低温的作用,且毒副作用未发生和增加。 Objective To explore the dose-effect and dose-toxicity relationship of the two kinds of slices,the ultrafine granular powder(UGP)of Radix et Rhizoma Ginseng Rubra(Hongshen)and its traditional decoction slice(DS),and to provide evidence for the safety and effectiveness of Hongshen UGP,we compared the anti-fatigue,anoxia-tolerant and low-temperature-resistant effect and acute toxicity of Hongshen UGP.Methods Mouse weightloaded test,normal-pressure hypoxia tolerance test,and low-temperature resistance test were carried out to compare the pharmacological actions of Hongshen UGP and Hongshen DS.And the maximum tolerated dose(MTD)was used to evaluate the difference in toxicity between the two kinds of slices.Results The efficiency of anti-fatigue,hypoxia tolerance and low-temperature resistance of Hongshen UGP was superior to that of the same dose of Hongshen DS(P<0.05);the low dose of Hongshen UGP had the same efficiency as that of 1/2 dose of Hongshen DS.No acute toxic reaction was observed in mice treated with Hongshen UGP by MTD(equivalent to 7-21 times of the clinical dosage of DS).Conclusion The preparation of UGP of Hongshen can reduce the dosage of Hongshen,and Hongshen UGP has the same anti-fatigue,anoxia-tolerant and low-temperature-resistant effect as Hongshen DS without occurrence of toxic or side effects.

关 键 词： 红参 破壁饮片 抗疲劳 耐缺氧 耐低温 急性毒性

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