作　　者： ; ; ;

机构地区： 粤北人民医院

出　　处： 《陕西医学杂志》 2020年第7期851-854,共4页

摘　　要： 目的:探讨非小细胞肺癌(NSCLC)化疗前后血清糖类抗原125(CA125)、肿瘤异常蛋白(TAP)水平变化及其与疗效的关系。方法:选取NSCLC患者120例作为NSCLC组,同期选取体检中心健康人员60例作为健康组,检查所有人员血清CA125、TAP水平,分析血清CA125、TAP水平与疗效的关系。结果:NSCLC组血清CA125、TAP水平明显高于健康组,比较差异有统计学意义(P<0.05);NSCLC组化疗后,完全缓解(CR)24例(20.00%)、部分缓解(PR)54例(45.00%)、稳定(SD)36例(30.00%)、进展(PD)6例(5.00%);CR、PR、PD患者化疗前后血清CA125、TAP水平及其下降比比较,差异有统计学意义(P<0.05),SD患者化疗前后血清CA125、TAP水平及其下降比比较,差异无统计学意义(P>0.05);ROC曲线分析结果显示,在评估NSCLC化疗有效性的敏感度、特异度、准确度方面,CA125下降比以>27%为临界值时为88.46%、69.48%、81.67%,TAP下降比以>18%为临界值时为85.90%、69.48%、80.00%,TAP联合CA125为96.15%、90.48%、94.17%,TAP联合CA125明显高于二者单独时,差异有统计学意义(P<0.05)。结论:NSCLC化疗前后血清CA125、TAP水平变化与疗效有关,检测血清CA125、TAP水平可作为评估患者化疗疗效的重要指标,且二者联合时具有更佳的效能。 Objective:To discuss the changes of serum carbohydrate antigen 125(CA 125)and tumor abnormal protein(TAP)levels before and after chemotherapy for non-small cell lung cancer(NSCLC)and their relationship with curative effect.Methods:120 patients with NSCLC were selected as NSCLC group.Meanwhile,60 healthy persons in the physical examination center were selected as health group.The serum levels of CA 125 and TAP were examined,and the relationship between serum CA 125 and TAP levels and curative effect was analyzed.Results:Serum CA 125 and TAP levels in NSCLC group were significantly higher than those in health group,and the difference was statistically significant(P<0.05).After chemotherapy,in group NSCLC,24 cases(20.00%)were completely remission(CR),partial remission(PR)was 54 cases(45.00%),stability(SD)was 36 cases(30.00%),progression(PD)was 6 cases(5.00%).The levels of serum CA 125 and TAP in patients with CR,PR and PD before and after chemotherapy were compared,and the difference was statistically significant(P<0.05).The serum levels of CA 125 and TAP in SD patients before and after chemotherapy were compared,and the difference was not statistically significant(P>0.05).ROC curve analysis showed that in terms of sensitivity,specificity and accuracy of evaluating the effectiveness of NSCLC chemotherapy,CA 125 was 88.46%,69.48%,81.67%when the critical value was>27%,and TAP was 85.90%,69.48%,80.00%when the critical value was>18%,and the combination of CA 125 and TAP was 96.15%、90.48%、94.17%(P<0.05).Conclusions:The changes of serum CA 125 and TAP levels were related to the curative effect before and after NSCLC chemotherapy.The detection of serum CA 125 and TAP levels can be used as an important indicator for evaluating the efficacy of chemotherapy in patients,and the combination of the two has better performance,which is worthy of further clinical promotion.

关 键 词： 非小细胞肺癌 化疗 糖类抗原 肿瘤异常蛋白 对比研究

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