作　　者： ;

机构地区： 广州中医药大学

出　　处： 《辽宁中医杂志》 2018年第12期2569-2572,共4页

摘　　要： 目的:探讨自拟疏肝开窍饮经验方联合盐酸氟桂利嗪片治疗偏头痛患者的临床效果,重点探究其对患者血清降钙素基因相关肽(calcium gene related peptide,CGRP)、5-羟色胺(5-hydroxytryptamine,5-HT)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平的影响。方法:将92例偏头痛患者机分为观察组及对照组各46例,对照组患者口服盐酸氟桂利嗪片,观察组患者则在对照组基础上加用自拟疏肝开窍饮经验方内服,连续用药1个月。对比两组治疗方案的临床疗效,记录并比较两组患者治疗前后的头痛发作频率、每月无头痛天数、疼痛持续时间,用疼痛视觉模拟评分法VAS对偏疼痛程度进行评定,采用超声经颅多普勒血流分析仪检查患者治疗前后脑血流动力学指标变化,监测治疗前后血清CGRP、5-HT、TNF-α水平,记录两组患者用药期间的不良反应。结果:观察组有效率91.3%明显高于对照组的71.7%(P<0.05);经治疗后观察组患者的头痛发作频率明显低于对照组,每月无头痛天数明显多于对照组,疼痛程度评分显著降低,疼痛持续时间明显缩短(P<0.05);观察组患者脑血流动力学指标MCA、BA、PCA、ACA水平较治疗前及对照组显著降低(P<0.05);观察组患者血清中CGRP、TNF-α水平较治疗前及对照组显著降低,5-HT水平较治疗前及对照组显著升高(P<0.05);观察组治疗期间不良反应率8.7%明显低于对照组的不良反应率21.74%(P<0.05)。结论:自拟疏肝开窍饮经验方联合盐酸氟桂利嗪片利于减轻患者头痛程度,其止痛机制可能是通过改善患者的脑血流动力、调控血清中CGRP、5-HT、TNF-α水平以改善神经元代谢与脑微循环、缓解血管痉挛等途径实现的,值得临床推广。 Objective:To investigate the clinical efficacy of self-prepared experiential formula Shugan Kaiqiao Decoction combined with flunarizine hydrochloride tablets in the treatment of migraine patients and its influence on the peripheral blood CGRP,5-HT and TNF-α levels.Methods:A total of 92 patients were randomly divided into a control group of 46 cases and an observation group of 46 cases.Patients in the control group were given flunarizine hydrochloride tablets;while patients in the observation group were treated with self-prepared experiential formula Shugan Kaiqiao Decoction on the basis of the control therapy,1 month for treatment.The paper was aimed at comparing the clinical curative effect of two groups of treatment plan,recorded and compared the two groups headache frequency,no headache days every month and pain duration before and after treatment,assessing the degree of pain by visual analog pain score(VAS)method,testing the cerebral hemodynamic index changes,monitoring the peripheral blood CGRP,5-HT and TNF-α levels,and recording the adverse reactions in the two groups.Results:The effective rate of the observation group was 91.3%,which was higher than that of the control group(P<0.05).Tthe frequency of headache attack in the observation group was significantly lower than that in the control group,and the number of days without headache per month was significantly higher than that in the control group,with significantly lower pain score and significantly shorter pain duration(P<0.05).The levels of MCA,BA,PCA and ACA in the observation group were significantly lower than those in the control group before treatment(P<0.05).The serum CGRP and TNF-α of the observation group were significantly lower than those of the control group,and the 5-HT level was significantly higher than that of the control group(P<0.05).During treatment,the adverse reaction rate of the observation group was 8.7%,which was significantly lower than the control group′s 21.74%(P<0.05).Conclusion:The therapy is helpful to reduce the heada

关 键 词： 偏头痛 自拟疏肝开窍饮经验方 盐酸氟桂利嗪片

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