作　　者： (）;

机构地区： 广东医科大学

出　　处： 《国际输血及血液学杂志》 2019年第3期223-228,共6页

摘　　要： 骨髓增殖性肿瘤(MPN)是一组造血干细胞异常克隆性疾病,其特征为分化相对成熟的一系或多系骨髓细胞持续克隆性增殖。该病主要包括慢性髓细胞白血病(CML)和Ph-MPN。近年文献报道,调节性T细胞(Treg)数量和功能的异常,在MPN的发生、发展中发挥重要作用。因此,笔者拟就Treg的生物学特征及其对MPN患者的作用,CML患者体内Treg数量与CML临床分期、Sokal评分、疗效及BCR-ABL融合基因转录水平的关系,以及Treg在Ph-MPN发病和进展中作用的研究进展进行综述。 Myeloproliferative neoplasms (MPN) are a group of abnormal clonal diseases of hematopoietic stem cell, which characterized by sustained clonal proliferation of relatively mature differentiated one or more myeloid cells. MPN mainly include chronic myeloid leukemia (CML) and Ph-/MPN. In recent years, studies have reported that abnormal number and function of regulatory T cell (Treg) play an important role in the occurrence and development of MPN. Therefore, this article reviews recent research advances in the biological characteristics of Treg, relationship between number of Treg in CML patients and CML clinical phase, Sokal score, efficacy and transcription level of BCR-ABL fusion gene, as well as the role of Treg in the pathogenesis and progression of Ph- MPN.

关 键 词： 淋巴细胞 淋巴细胞 调节 骨髓增殖性疾病 白血病 髓系 慢性 阳性 治疗结果 肿瘤分期

领　　域： []