作　　者： ;

机构地区： 广东药科大学中药学院

出　　处： 《中国药理学通报》 2019年第9期1325-1331,共7页

摘　　要： 目的建立红色毛癣菌感染豚鼠模型的评价指标体系,综合评价不同的造模方法,优选红色毛癣菌皮肤感染动物模型。方法通过文献调研和专家咨询确定模型评价指标,利用德尔菲法和层次分析法计算出各指标权重,建立红色毛癣菌感染豚鼠模型的综合评价指标体系,进一步以此体系综合评价多种红色毛癣菌皮肤感染动物模型,优选理想的动物模型。结果实验结果确认该评价体系良好;接受免疫抑制剂处理并重复接种红色毛癣菌的动物模型质量较佳,成功率更高。结论本研究采用层次分析法建立的评价指标体系清晰、简便,优选的红色毛癣菌皮肤感染动物模型适合推广用于抗真菌药的药效学评价。 Aim To establish the evaluation system for guinea pig skin infection model of Trichophyton rubrum , and to evaluate different modeling methods and select the best skin infection ani- mal model of Trichophyton rubrum . Methods The evaluation index was determined by literature research and expert consultation, weight of each index was calculated by Delphi Method and the analytic hierarchy process(AHP), to establish a comprehensive evaluation system for guinea pig skin infection model of Trichophyton rubrum . Furthermore, various skin infection animal models of Trichophyton rubrum were evaluated by this system and the ideal animal model was selected. Results The evaluation system proved to be available. The animal model with immunosuppressive treatment and repeated inoculation with Trichophyton rubrum had better quality and higher success rate. Conclusions The evaluation system established by AHP is clear, simple and convenient;the optimized skin infection animal model of Trichophyton rubrum is suitable for the efficacy evaluation of anti-fungal infection drugs.

关 键 词： 层次分析法 模型评价 红色毛癣菌 皮肤感染 免疫抑制 豚鼠

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