作　　者： ; ; ; ;

机构地区： 广东省现场流行病学培训项目广东广州511430

出　　处： 《中国疫苗和免疫》 2019年第2期176-179,共4页

摘　　要： 目的了解佛山市顺德区2014-2015年健康人群白喉抗体水平。方法采取分层随机抽样方法,在全区10个镇/街道选择0-63岁健康人群采集血清标本,采用酶联免疫吸附试验(ELISA)检测白喉IgG抗体,分析白喉抗体水平。结果调查人群白喉IgG抗体阳性率为73.30%(324/442),抗体几何平均浓度(GMC)为0.32IU/mL。本地、外地户籍人群抗体阳性率分别为79.05%(234/296)、61.64%(90/146)(χ2=15.14,P<0.01)。抗体阳性率在4岁(94.12%)、8或9岁(100%)达到高峰,随后逐渐降至21-30岁的53.57%、≥31岁的38.24%。含白喉成分疫苗接种剂次越多,阳性率越高(趋势χ2=72.51,P<0.01);接种年限越长,阳性率越低(趋势χ2=4.53,P=0.03)。结论顺德区健康人群已形成有效的白喉免疫屏障。建议>20岁往来于白喉流行国家或地区人群定期加强免疫1剂次含白喉成分疫苗。 Objective To evaluate diphtheria antibody levels of healthy people in Shunde district of Foshan city during2014-2015.Methods We used stratified random sampling to obtain serum samples f rom 0-63 year old healthy people in10 townships of Shunde.We tested sera for diphtheria IgG antibody by enzyme-linked immunosorbent assay(ELISA)and analyzed diphtheria antibody levels.Results The positivity rate and geometric mean concentration(GMC)of diphtheria IgG antibody among subjects were 73.30%(324/442)and 0.32 IU/mL,respectively.Positivity rates among local and non-local subjects were 79.05%(234/296)and 61.64%(90/146),respectively(χ2=15.14,P<0.01).Positivity rates peaked at 4 years of age(94.12%),and 8 or 9 years of age(100%),and then gradually decreased to 53.57%among 21-30 year olds and 38.24%among≥31 year olds.Receiving more doses of diphtheria containing vaccine was associated with higher sero-positivity(trendχ2=72.51,P<0.01).Longer time since vaccination was associated with lower sero-positivity(trendχ2=4.53,P=0.03).Conclusions An effective immunity barrier against diphtheria has been formed among healthy people in Shunde.We recommend 1 booster dose of diphtheria containing vaccine for>20-yearold people travelling to diphtheria-endemic countries or regions.

关 键 词： 白喉 抗体水平

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