作　　者： ; ;

机构地区： 深圳市宝安区石岩人民医院

出　　处： 《中国医学创新》 2020年第16期153-156,共4页

摘　　要： 目的:探讨宫颈上皮内瘤变(CIN)患者不同亚型人乳头瘤病毒(HPV)感染的流行病学特征.方法:回顾性分析本院2019年2-10月慢性宫颈炎、CINⅠ、CINⅡ及CINⅢ患者各200例的临床资料.通过PCR-反向点杂交法对各组HPV感染情况进行检测并比较,分析不同宫颈病变中低危型及高危型HPV感染的分布情况.结果:慢性宫颈炎组检测出病毒株260株,CINⅠ组检测出病毒株287株,CINⅡ组检测出病毒株280株、CINⅢ组检测出病毒株269株.慢性宫颈炎组与CINⅠ组低危型HPV感染率均高于CINⅡ组与CINⅢ组,而高危型HPV感染率均低于CINⅡ组与CINⅢ组(P<0.05).四组感染低危型HPV中HPV42与HPV43比例均高于HPV6、HPV11与HPV81(P<0.05).CINⅢ组感染HPV11比例明显低于CINⅠ组,且CINⅡ组感染HPV42与HPV43比例均高于慢性宫颈炎组(P<0.05).CINⅡ组与CINⅢ组感染高危型HPV中HPV16比例高于慢性宫颈炎组,而慢性宫颈炎组、CINⅡ组与CINⅢ组感染HPV33比例高于CINⅠ组(P<0.05).CINⅡ组与CINⅢ组感染的高危型HPV以HPV16、HPV52、HPV58为主.结论:慢性宫颈炎以及CINⅠ病变中HPV感染主要以HPV42、HPV43等低危型HPV感染为主,而CINⅡ、CINⅢ病变中HPV感染主要以HPV16、HPV52、HPV58等高危型HPV感染为主.临床工作中可通过对上述特殊高危病毒类型予以重点关注,同时进行密切随访,继而达到降低宫颈癌发生的目的. Objective:To investigate the epidemiological characteristics of human papillomavirus(HPV)infection in different subtypes of patients with cervical intraepithelial neoplasia(CIN).Method:The clinical data of 200 cases of chronic cervicitis,CINⅠ,CINⅡand CINⅢin our hospital from February to October 2019 were analyzed retrospectively.HPV infection in each group was detected and compared by PCR-reverse point hybridization,and the distribution of low-risk and high-risk HPV infection in different cervical lesions were analyzed.Result:A total of 260 strains of the virus were detected in chronic cervicitis group,287 strains in CINⅠgroup,280 strains in CINⅡgroup and 269 strains in CINⅢgroup.The infection rate of low-risk HPV in chronic cervicitis group and CINⅠgroup were higher than those in CINⅡand CINⅢgroup,while the infection rate of high-risk HPV were lower than those in CINⅡand CINⅢgroup(P<0.05).The proportion of HPV42 and HPV43 in four groups with low-risk HPV infection strains were higher than those of HPV6,HPV11 and HPV81(P<0.05).The proportion of HPV11 infection in CINⅢgroup was significantly lower than that in CINⅠgroup,and the proportion of HPV42 and HPV43 infection in CINⅡgroup were higher than those in chronic cervicitis group(P<0.05).The proportion of HPV16 infection in CINⅡand CINⅢgroup were higher than those in chronic cervicitis group,while the proportion of HPV33 infection in chronic cervicitis group,CINⅡand CINⅢgroup were higher than those in CINⅠgroup(P<0.05).HPV16,HPV52 and HPV58 were the main high-risk HPVs in CINⅡand CINⅢgroups.Conclusion:In chronic cervicitis and CINI lesions,HPV infection is mainly of low-risk HPV,such as HPV42 and HPV43,while in CINⅡand CINⅢlesions,HPV infection is mainly of high-risk HPV,such as HPV16,HPV52 and HPV58.In the clinical work,we can pay more attention to the above special high-risk virus types and make close follow-up,so as to reduce the incidence of cervical cancer.

关 键 词： 宫颈上皮内瘤变 人乳头瘤病毒 流行病学

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