作　　者： (）;

机构地区： 广州中医药大学附属南海妇产儿童医院

出　　处： 《中国当代医药》 2019年第19期8-11,共4页

摘　　要： 目的探讨早产和足月新生儿坏死性小肠结肠炎(NEC)发病的影响因素。方法回顾性分析2006年1月~2018年9月在我院分娩并确诊为NEC的93例新生儿的临床资料,按照胎龄将其分为早产儿NEC组(36例)和足月儿NEC组(57例)。同时根据相似的胎龄、体重选择同期入住我院新生儿科的186例非NEC新生儿,按照胎龄将其分为早产儿对照组(72例)和足月儿对照组(114例),分别对早产儿和足月儿的NEC发病特点及可能影响NEC发病的各种因素进行分析。结果早产儿NEC的发病日龄与胎龄成负相关(r=-0.568,P=0.000);足月儿NEC的发病日龄与胎龄无显著相关性(r=-0.047,P=0.729),与母亲分娩年龄亦无显著相关性(r=0.146,P=0.277)。早产儿中,NEC组与对照组患儿的口服益生菌及呼吸窘迫综合征(RDS)情况比较,差异有统计学意义(P<0.05);足月儿中,NEC组与对照组的贫血及高胆红素血症情况比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在早产儿中,口服益生菌是NEC的保护因素(β=-2.003,OR=0.135,95%CI:0.053~0.346,P=0.000),RDS是NEC的危险因素(β=1.456,OR=4.289,95%CI:1.309~14.059,P=0.016);在足月儿中,贫血是NEC的危险因素(β=1.142,OR=3.132,95%CI:1.568~6.256,P=0.001),高胆红素血症是NEC的保护因素(β=-2.386,OR=0.092,95%CI:0.017~0.498,P=0.006)。结论在早产儿中,口服益生菌是NEC的保护因素,RDS是NEC的危险因素;在足月儿中,高胆红素血症是NEC的保护因素,贫血是NEC的危险因素。 Objective To investigate the influencing factors of necrotizing enterocolitis (NEC) in preterm and full-term neonates. Methods The clinical data of 93 neonates born in our hospital from January 2006 to September 2018 and diagnosed with NEC were retrospectively analyzed. According to gestational age, they were divided into preterm NEC group (36 cases) and full-term NEC group (57 cases). At the same time, according to the similar gestational age and body weight, 186 non-NEC neonates who were admitted to the neonatology department of our hospital during the same period were divided into the preterm control group (72 cases) and the full-term control group (114 cases) according to gestational age. The characteristics of NEC in preterm and term infants and various factors that might affect the incidence of NEC were analyzed. Results The age of onset of NEC in preterm infants was negatively correlated with gestational age (r=-0.568, P=0.000). There was no significant correlation between the age of onset NEC and gestational age in the term infants (r=-0.047, P=0.729), and there was no significant correlation between the age of onset NEC and mother delivery age (r=0.146, P=0.277). In the preterm infants, there were significant differences in oral probiotics and respiratory distress syndrome (RDS) between the NEC group and the control group (P<0.05). In the full-term infants, there were significant differences in anemia and hyperbilirubinemia between the NEC group and the control group (P<0.05). Multivariate Logistic regression analysis showed that oral probiotics was the protective factors for NEC in preterm infants (β=-2.003, OR=0.135, 95%CI: 0.053-0.346, P=0.000), and RDS was the risk factor for NEC (β=1.456, OR=4.289, 95%CI: 1.309-14.059, P=0.016). In full-term infants, anemia was the risk factor for NEC (β=1.142, OR=3.132, 95%CI: 1.568-6.256, P=0.001), and hyperbilirubinemia was the protective factor for NEC (β=-2.386, OR=0.092, 95%CI: 0.017-0.498, P=0.006). Conclusion Oral probiotics is a protective factor and RD

关 键 词： 坏死性小肠结肠炎 早产儿 足月儿 危险因素

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