作　　者： (）;

机构地区： 广州医科大学公共卫生学院

出　　处： 《中华预防医学杂志》 2019年第5期450-454,共5页

摘　　要： 环境化学物暴露与疾病的发生和发展密切相关,非编码RNA的异常表达是环境化学物生物学效应的重要因素。非编码RNA在维持细胞正常功能与影响疾病发生发展方面均发挥重要作用,并具有机制性意义。此外,非编码还可作为生物标志物,有潜力在疾病诊断、治疗和预防中得以广泛应用。本文概述了环境化学物暴露与非编码RNA表达的关系、非编码RNA的功能及作用机制,并提出了现有研究中存在的问题,对未来发展作了展望。 Environmental chemicals exposure is closely related to occurrence and development of diseases.The abnormal expression of non-coding RNAs is a key factor in biological effects of environmental chemicals.Non-coding RNAs play an important role in the normal function of cells and the occurrence and development of diseases.In addition,non-coding RNAs,as a biomarker,could be widely used in the diagnosis,prevention and treatment of diseases.This paper outlines the relationship between environmental chemical exposure and non-coding RNAs and the function and mechanism of non-coding RNAs.It also presents existing issues and future research directions.

关 键 词： 环境暴露 危害物质 遗传 非编码

领　　域： []