作　　者： ;

机构地区： 东莞职业技术学院

出　　处： 《生殖医学杂志》 2014年第11期884-888,共5页

摘　　要： 目的探讨不同促排卵方案对宫腔内人工授精（IUI）妊娠结局的影响。方法收集2009年4月至2014年4月期间在本院生殖中心,采用自然周期（NC）和克罗米芬（CC）、来曲唑（LE）、人绝经期促性腺激素（HMG）、CC＋HMG和LE＋HMG 5种促排卵方案用于IUI共2 528周期,并对其临床资料进行回顾性分析。结果 （1）NC组、CC组、LE组、HMG组、CC＋HMG组、LE＋HMG组的临床妊娠率分别为9.49%、13.74%、14.95%、15.73%、19.13%、21.80%;5个促排卵组的临床妊娠率高于NC组,差异具有统计学意义（P〈0.05）;LE＋HMG组临床妊娠率高于CC组、LE组、HMG组,差异亦具有统计学意义（P〈0.05）,与CC＋HMG组比较差异无统计学意义（P〉0.05）。（2）NC组、CC组、LE组、HMG组、CC＋HMG组和LE＋HMG组多胎妊娠率分别0%、4.26%、2.38%、9.88%、9.52%、1.72%;促排卵周期组总多胎妊娠率及其中HMG组、CC＋HMG组多胎妊娠率高于NC组,差异具有统计学意义（P〈0.05）;5个促排卵组多胎妊娠率组间比较无统计学差异（P〉0.05）。（3）NC组、CC组、LE组、HMG组、CC＋HMG组和LE＋HMG组自然流产率、异位妊娠率的组间比较无统计学差异（P〉0.05）。结论促排卵治疗可提高IUI的临床妊娠率,对自然流产率和异位妊娠率无明显影响,但增加多胎妊娠率。LE＋HMG方案可以提高临床妊娠率,多胎妊娠率和自然流产率较低,值得在临床推广。 Objective ： insemination（I To study the effect of different ovulation induction protocols on the outcome of intrauterine UI） Methods： A retrospective study was done to analyze the data of 2 528 IUI cycles in IVF Center of Sun Yet-sen Memorial Hospital from April 2009 to April 2014. According to different ovulation induction protocols,the patients were divided into six groups： NC （natural cycle）group, CC （clomiphene citrate） group, LE（letrozole） group, HMG （ human menopausal gonadotropin） group, CC if- HMG group and LE＋ HMG group. Results： The pregnancy rates were 9.49%, 13.74%, 14.95%, 15. 73%, 19.13%, and 21. 80% respectively for the six groups. The clinical pregnancy rates of CC group, LE group, HMG group, CC＋ HMG group and LE＋ HMG group were significantly higher than those of NC group （P 〈 0.05）. The clinical pregnancy rate of LE＋ HMG group were significantly higher than that of CC group, LE group and HMG group（P〈0.05） ,and no statistical difference was found when compared with the other two groups （P~0. 05）. The multiple pregnancy rates were0%,4.26%,2.38%,9.88%,9.52% and 1.72% in the six groups respectively. The multiple pregnancy rate in ovulation induction cycle, HMG group,CC＋ HMG group were significantly higher than that of NC group（P〈0.05）. And no statistical differences of multiple pregnancy rates were found among the five groups of ovulation induction cycle（P〉0.05）. No statistical differences were found in the abortion rate and the ectopic pregnancy rate among the five groups of ovulation induction cycle（P〉0. 05）. Conclusions. The clinical pregnancy rate of ovulation induction cycle is higher than that of the natural cycle,but ovulation induction increases the multiple pregnancy rate. The LE＋HMG protocol can increase clinical pregnancy rate,and decrease the multiple pregnancy rate and the abortion rate. It may be a good choice for IUI.

关 键 词： 宫腔内人工授精 自然周期 促排卵 临床妊娠率

分 类 号： [R]

领　　域： []