作　　者： (李玲玲）; (纪秋琴）; (周晓鸿）; (张佩莲）;

机构地区： 昆明医科大学第二附属医院皮肤科,云南昆明650101

出　　处： 《临床皮肤科杂志》 2017年第9期636-638,共3页

摘　　要： 报告1例棘层松解浸润性原发性乳房外Paget病。患者男,66岁。会阴红斑溃疡10余年。皮肤科检查:阴茎、阴囊及阴阜大片红斑及溃疡,其上有大小不等的结节及大量脓性分泌物。皮损组织病理:表皮棘层明显增生肥厚,向真皮内浸润,细胞排列絮乱,异形明显,可见核分裂象及角化不良细胞,真皮内可见少量鳞状细胞团块,周围大量炎性细胞浸润。腹股沟淋巴结组织病理:淋巴结内见Paget样细胞浸润。诊断:棘层松解浸润性原发性乳房外Paget病。 A 66-year-old male presented with erythema and ulcer in the perineum for more than 10 years. Physical examination revealed that penis, scrotum and mons pubis have large erythema and ulcerative damage, which has varying degrees of hyperplastic nodules and a large number of purulent secretions. Histopathologic examination showed hypertrophic acanthosis and acantholysis of the epidermis, single or nested Paget-like cells of the epidermis and upper dermis, which showing invasire growth. Pathology for inguinal lymph node showed metastasis of adenocarcinoma in the lymph node, considering the metastasis of invasive Paget＇s disease. According to histopathological and immunohistoehemical results, the diagnosis was acan-tholytic invasive primary extrammary Paget＇s disease.

关 键 词： 乳房外 病 棘层松解性