作　　者： (任勇）; (何威）; (陈昕薇）; (梁励玮）; (冯俊明）;

机构地区： 解放军武汉总医院病理科,湖北武汉430070

出　　处： 《华南国防医学杂志》 2017年第6期359-362,共4页

摘　　要： 目的探讨肿瘤内皮标志物8(tumor endothelial marker 8,TEM8)蛋白在非小细胞肺癌(non-small cell lung cancer,NSCLC)及癌旁正常肺组织中的表达特点及其临床意义。方法采用免疫组织化学法检测110例NSCLC及30例癌旁正常肺组织中TEM8蛋白的表达,并分析TEM8表达与临床病理特征及预后的关系。结果TEM8在NSCLC中的阳性率(52.72%)明显高于癌旁正常肺组织(6.67%)(P<0.01),TEM8的表达与NSCLC的肿瘤分化程度、TNM分期(T指原发灶的情况,N指区域淋巴结受累情况,M指远处转移)和有无淋巴结转移相关(P<0.05)。Kaplan-Meier生存分析显示NSCLC中TEM8蛋白表达与患者术后总生存率呈负相关(P<0.05)。结论 TEM8高表达与NSCLC的进展和预后显著相关,可作为NSCLC患者预后判断的指标。 Objective To investigate the expression and clinical significance of tumor endothelial marker 8 （TEM8） protein in non-small cell lung cancer （NSCLC） and adjacent non-cancerous normal lung tissues. Methods TEM8 expres- sions were evaluated in NSCLC tissues （n = 110） and adjacent normal lung tissues （n = 30） by immunohistochemistry. The correlation between TEM8 expressions and NSCLC clinicopathological parameters, and survival rates were analyzed by statistical methods. Results The positive expression rate of TEM8 was significantly higher in NSCLC tissues （52. 72%） than that in adjacent normal lung tissues （6. 67%） （P〈0. 01）, The expression of TEM8 in NSCLC was correlated with differentiation degree, TNM stage and lymph node metastasis （P〈0. 05）. Kaplan-Meier survival analysis suggested that the positive expression of TEM8 was negatively correlated with the overall survival rate （P〈0. 05）. Conclusion High level of TEM8 expression is significantly correlated with NSCLC progression and poor prognosis, so it can be used as a novel NSCLC biomarker.

关 键 词： 非小细胞肺癌 肿瘤内皮标志物 预后 免疫组织化学