作　　者： (赵金城）;

机构地区： 山东省庆云县人民医院,山东德州253000

出　　处： 《系统医学》 2017年第7期61-64,共4页

摘　　要： 目的分析探讨小剂量糖皮质激素在治疗HBV相关慢加急性肝衰竭的具体效果与安全性能。方法该次研究主要选取该院2015年9月—2016年9月收治的118例HBV相关慢加急性肝衰竭患者为研究对象,按照纳入及排除比例将其随机分为观察组与对照组,且每组均为59例患者。所有患者均使用恩替卡韦抗病毒进行治疗,并辅助常规护肝的治疗方法。且观察组在此基础上使用小剂量氢化可的松琥珀酸钠进行静脉注射治疗。期间,医护人员应观察记录所有患者的临床症状、不良反应、住院时间、治疗费用以及肝功能生化指标等内容。结果治疗结束之后,观察组患者的抗病毒治疗效果为88%,对照组为77%;肝功能生化指标中Alb观察组治疗后为(35.19±3.79)g/L,对照组为(26.78±3.79)g/L;Ch E观察组治疗后为(6 557.61±669.62)U/L,对照组为(3 272.00±495.78)U/L。各指标结果均好于对照组,差异有统计学意义(P<0.05)。结论小剂量氢化可的松琥珀酸钠可以有效治疗HBV相关慢加急性肝衰竭疾病,且可以有效改善预后情况,缩短住院时间,具备较好的安全性能,值得在实际临床中得到进一步应用。 Objective To analyze and discuss the specific effect and safety of small-dose glucocorticosteroid in treat- ment of HBV-related acute-on-chronic liver failure. Methods 118 cases of patients with HBV-related acute-on- chronic liver failure admitted and treated in our hospital from September 2015 to September 2016 were selected as the research objects and randomly divided into two groups with 59 cases in each, all patients adopted the entecavir anti- virus treatment and routine liver-protected treatment method, while the observation group adopted the intravenous treatment of small-dose sodium succinate on the basis of the control group, and the clinical symptoms, adverse reaction, length of stay, treatment cost and liver function biochemical indexes of all patients were observed and recorded by the medical staff. Results At the end of treatment, the anti-virus treatment effect in the observation group and 88% and 77% in the control group, and the Alb in the liver function biochemical index after treatment in the observation group was （35.19±3.79）g/L and （26.78±3.79）g/L in the control group, after treatment, the ChE was （6 557.61±669.62）U/L in the observation group and（3 272.00±495.78）U/L in the control group, and the results of various indexes were better than those in the control group, and the differences were statistically significant（P〈0.05）. Conclusion The small-dose hydro- cortisone sodium suceinate can effectively treat the HBV-related acute-on-chronic liver failure and effectively improve the prognosis, shorten the length of stay with a better safety performance, which is worth further application in clinic.

关 键 词： 小剂量糖皮质激素 相关慢加急性肝衰竭 效果观察