作　　者： (闵志强）; (蒋淼）; (石娅萍）;

机构地区： 成都中医药大学,四川成都611137

出　　处： 《中药与临床》 2017年第1期42-44,共3页

摘　　要： 目的:验证固体分散技术可提高青黛药效。方法:取KM小鼠,按体重随机分为正常对照组、模型对照组、美沙拉嗪组、青黛配方分散片组、青黛饮片组。除正常组小鼠外,其余小鼠自由饮用5%DSS5天建立溃疡性结肠炎模型,造模后第6 d开始给药,治疗7 d。造模及给药期间观察小鼠大便、体重、摄食、活动等,进行DAI评分,末次给药后4 h后处死小鼠,取结肠进行病理检查。结果:两种青黛饮片对小鼠结肠损伤有不同程度修复作用,且青黛配方分散片疗效优于青黛原饮片。结论:固体分散技术可提高青黛的药效作用。 Objective： To investigate the solid dispersion technology on the efficacy of Qingdai. Method： The KM mice were randomly divided into normal control group, model control group, mesalazine group, Qingdai dispersible tablet group, and Qingdai decoction pieces group. Except the normal control group, mice were freely access to 5%DSS drinking for 5 days to establish ulcerative colitis model. At the sixth day after model establishment, the mice was given drugs for 7 days. During the model establishment and drug administration, the stool, body weight, feeding and activity of mice were observed, and DAI score was recorded. At 4 h after the last administration, the mice were sacrificed and the colon was taken for pathological examination. Result： Both two Qingdai dosage forms had a certain degree of repairing effect on mice colonic damage, and Qingda formula dispersible tablet showed a better effect than Qingdai decoction pieces. Conclusion： Solid dispersion technology can improve the efficacy of Qingdai.

关 键 词： 青黛 固体分散 结肠炎