作　　者： (孙琳）; (刘文君）; (于少娟）;

机构地区： 陕西省西安铁路工程医院内科,陕西西安710600

出　　处： 《海南医学院学报》 2017年第13期1762-1765,共4页

摘　　要： 目的:探讨丹红注射液对缺血性心肌病心力衰竭患者神经内分泌分子、心室重构的影响。方法:收集在本院接受治疗的缺血性心肌病心力衰竭患者80例,随机分为对照组、观察组各40例。对照组接受常规治疗,观察组接受常规+丹红注射液治疗,14天一个疗程,连用两个疗程。对比两组治疗前后血清中神经内分泌分子、心室重构相关指标的含量,多普勒超声心室重构参数水平等差异。结果:治疗前,两组血清中神经内分泌分子、心室重构相关指标的含量以及多普勒超声心室重构参数的水平均无统计学差异。治疗后,观察组血清中神经内分泌分子NT-proBNP、ANP、AngⅡ、ALD、NE的含量低于对照组,血清中心室重构指标TGF-β1、NF-κB、CysC、FGF23的含量低于对照组,超声心室重构参数LVMI、LVRI、RVEDV、RVESV的水平低于对照组。结论:缺血性心肌病心力衰竭患者接受丹红注射液辅助治疗,有助于神经内分泌分子含量的优化并抑制心室重构进程。 Objective：To study the effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure.Methods：A total of 80 cases of patients with ischemic cardiomyopathy heart failure who were treated in our hospital between March 2014 and December 2016 were collected and divided into control group（n=40）and observation group（n=40）according to random number table.The control group received regular treatment,the observation group received regular＋ Danhong injection treatment,and both therapies lasted for 14 days a course,two sessions.Serum contents of neuroendocrine molecules and ventricular remodeling-related indexes,Doppler ultrasonic ventricular remodeling parameter levels,and so on were compared between two groups of patients before and after treatment.Results：：Before treatment,serum contents of neuroendocrine molecules and ventricular remodeling-related indexes as well as Doppler ultrasonic ventricular remodeling parameter levels were not statistically different between two groups of patients.After treatment,serum neuroendocrine molecules NT-proBNP,ANP,AngⅡ,ALD and NE contents of observation group were lower than those of control group,serum ventricular remodeling indexes TGF-β1,NF-κB,CysC and FGF23 contents were lower than those of control group,and ultrasonic ventricular remodeling parameters LVMI,LVRI,RVEDV and RVESV levels were lower than those of control group.Conclusions：Adjuvant Danhong injection therapy helps optimize the neuroendocrine molecule contents and inhibit the ventricular remodeling process in patients with ischemic cardiomyopathy heart failure.

关 键 词： 缺血性心肌病 心力衰竭 丹红注射液 神经内分泌 心室重构