作　　者： (李燕）; (安志杰）; (刘燕敏）; (李琦）; (马玉杰）; (殷大鹏）; (王华庆）;

机构地区： 中国疾病预防控制中心免疫规划中心,北京100050

出　　处： 《中国疫苗和免疫》 2017年第4期361-364,共4页

摘　　要： 目的了解中国b型流感嗜血杆菌(Hib)疫苗加强免疫前后的免疫保护水平,为制定中国Hib疫苗免疫策略提供参考。方法在2个县选择已完成3剂Hib疫苗接种的健康儿童作为研究对象,分别于加强免疫前后采血检测抗Hib荚膜多糖抗体。结果在119名纳入研究对象中,加强免疫前、后血清抗Hib抗体浓度≥0.15μg/ml的比例均为100%;抗体浓度≥1.0μg/ml的比例分别为88.2%(105/119)、96.6%(115/119)(χ~2=6.01,P=0.01);抗体几何平均浓度(GMC)分别为3.60(95%CI:3.03-4.28)μg/ml、6.77(95%CI:5.96-7.68)μg/ml(t=5.93,P=0.00)。结论 Hib疫苗加强免疫能诱导免疫记忆反应,产生更高比例的长期保护力和更高的抗体水平。 Objective To evaluate the immunogenicity of a Haemophilus influenza type b（Hib） vaccine booster dose,and to provide additional evidence for refining Hib immunization strategy. Methods We selected healthy children who had received 3 doses of Hib vaccine in 2 counties as subjects. Blood samples were collected from all subjects before and one month after the Hib vaccine booster dose,and used for detection of Hib PRP Ig G antibody. Results Among the 119 subjects,before and after the booster doses,the proportions of subjects with Hib antibody concentrations ≥0. 15μg/ml were both 100%; the proportions with antibody concentrations ≥1. 0μg/ml were 88. 2%（105/119） and 96. 6%（115/119）（χ~2= 6. 01,P = 0. 01）,respectively;and the geometric mean concentrations（GMCs） of antibody were 3. 60（95% CI： 3. 03-4. 28） μg/ml and6. 77（95% CI： 5. 96-7. 68） μg/ml（t = 5. 93,P = 0. 00）,respectively. Conclusions A booster dose of Hib vaccine can induce immune memory and lead to a higher proportion of children with long term protection and with higher antibody levels.

关 键 词： 型流感嗜血杆菌疫苗 加强免疫 免疫原性