作　　者： (李瑾娴）; (陈建宁）; (黄淑英）; (李腾蛟）; (许良杰）; (许敏鸿）; (郭义龙）;

机构地区： 汕头市皮肤病医院,广东汕头515000

出　　处： 《皮肤病与性病》 2017年第4期247-249,共3页

摘　　要： 目的探究小剂量羟氯喹联合0.03%他克莫司软膏治疗面部激素依赖性皮炎的临床疗效。方法选取2015年5月至2017年2月皮肤科门诊就诊的面部激素依赖性皮炎患者100例,随机分为ABCD四组。A组患者口服盐酸左西替利嗪片,5mg/次,1次/d及外用氧化锌软膏于患处,2次/d;B组患者口服盐酸左西替利嗪片,5 mg/次,1次/d及外用0.03%他克莫司软膏于患处,2次/d;C组口服硫酸羟氯喹片,0.1g/次,2次/d及外用氧化锌软膏于患处,2次/d;D组口服硫酸羟氯喹片,0.1g/次,2次/d及外用0.03%他克莫司软膏于患处,2次/d。四组均连续治疗6周。观察四组的临床疗效,同时比较四组的反跳发生率。结果治疗后,ABCD组的总有效率分别为52%、72%、84%、96%,四组比较差异具有统计学意义(P<0.05)。ABCD组反跳发生率分别为46.2%、22.2%、9.1%、4.2%,差异具有统计学意义(P<0.05)。结论小剂量羟氯喹联合0.03%他克莫司软膏治疗面部激素依赖性皮炎具有较好的临床疗效,且反跳发生率低。 Objective To evaluate the efficacy and safety of low-dose hydroxychloroquine sulfate combined with 0.03% tacrolimus ointment in the treat- ment of facial hormone-dependent dermatitis. Methods One-hundred patients with facial hormone-dependent dermatitis, which were selected from outpa- tients from May, 2015 to Feb, 2017, and were randomly divided into four groups. The group A received levocetirizine tablets orally, once a day, and topical zinc oxide ointment, twice a day. The group B received levocetirizine tablets orally, once a day, and topical 0.03 % tacrolimus ointment, twice a day. The group C received low-dose hydroxychlorequine sulfate orally and topical zinc oxide ointment, twice a day. The group D received low-dose hydroxychloro- quine sulfate orally and topical O. 03% tacrolimus ointment, twice a day. The duration of treatment lasted for 6 weeks. Results The total effective rate of group ABCD was 52%, 72% , 84% and 96% , respectively, and the difference between the four groups was statistically significant （ P〈O. 05）. The recur- rence of group was 46.2%, 22.2%, 9. 1% and 4. 2%, respectively, and the difference was statistically significant （P〈0. 05 ）. Conclusion It is maybe more effective to treat facial hormone-dependent dermatitis with low-dose hydroxychloroquine sulfate combined with tacrolimus ointment, which with repidly effect, less side effects and low bounce.

关 键 词： 硫酸羟氯喹片 他克莫司软膏 面部激素依赖性皮炎 治疗