作　　者： (杨勇勋）; (张建平）; (王群）; (李慧梁）;

机构地区： 西昌学院动物科学学院,四川西昌615000 第二军医大学药学院,上海200433

出　　处： 《中草药》 2017年第15期3037-3041,共5页

摘　　要： 目的研究贵州天名精Carpesium faberi全草的化学成分。方法采用硅胶、C18反相硅胶、Sephadex LH-20等色谱技术与半制备HPLC色谱分离纯化,并根据理化性质与光谱数据鉴定化合物的结构。结果从贵州天名精全草丙酮提取物中分离得到12个化合物,包括1个二萜、1个生物碱、5个单萜、2个黄酮、2个木脂素及1个黄酮木脂素二聚体,分别鉴定为ent-kaurane-3β,16β,17-triol(1)、3-(hydroxy-acetyl)-1H-indole(2)、8,9,10-trihydroxythymol(3)、8-hydroxy-9,10-diisobutyryloxy-thymol(4)、香橙醇-β-D-吡喃葡萄糖苷(5)、(3S)-linalyl-β-D-glucopyranoside(6)、(1R,2S,4S,5R)-2,5-二羟基-p-薄荷烷(7)、木犀草素(8)、芹菜素-7-O-β-D-吡喃葡萄糖(9)、medioresinol(10)、松脂素(11)、水飞蓟素与异水飞蓟素的混合物(12)。结论化合物1~6、8~12为首次从本属植物中发现。 Objective To investigate the chemical constituents from the whole plant of Carpesium faberi. Methods Compounds were isolated by various chromatographic techniques, including silica gel, ODS, sephadex LH-20, and semi-preparative HPLC, and their structures were identified by comparison of their experimental spectroscopic data with their reported data. Results The phytochemistry investigation led to the isolation of 12 compounds, and their structures were elucidated as ent-kaurane-3β,16β,17-triol（1）, 3-（hydroxy-acetyl）-1H-indole（2）, 8,9,10-trihydroxythymol（3）, 8-hydroxy-9,10-diisobutyryloxy-thymol（4）, neryl-β-Dglucopyranoside（5）,（3S）-linalyl-β-D-glucopyranoside（6）,（1R,2S,4S,5R）-2,5-dihydroxy-p-menthane（7）, luteolin（8）, apigenin-7-O-β-D-glucopyranoside（9）, medioresinol（10）, pinoresinol（11）, and a mixture of silybin and isosilybin（12）. Conclusion All compounds except compound 7 are not only isolated from this plant for the first time, but also from this genus for the first time.

关 键 词： 贵州天名精 香橙醇 吡喃葡萄糖苷 木犀草素 芹菜素 吡喃葡萄糖 松脂素 水飞蓟素