作　　者： (胡晓霞）; (董乾）; (郝红）;

机构地区： 西北大学化工学院,陕西西安710069

出　　处： 《高分子材料科学与工程》 2017年第8期32-37,共6页

摘　　要： 以聚乙二醇为引发剂,L-丙交酯为单体,开环聚合得到聚乳酸-聚乙二醇三嵌段共聚物(PLLA-PEG-PLLA),采用溶剂挥发法制备了PLLA-PEG-PLLA/Fe_3O_4磁性微球,并通过扫描电镜对其形态进行了表征。利用振动样品磁强计和Tg研究了微球的磁含量和磁性能,结果发现,相同粒径不同磁含量的磁性微球,磁含量越高,升温速率越快,当磁含量为70.57%时,升温速率最快,能达到磁热疗的有效温度42℃。对于磁含量相同,粒径不同的微粒,粒径越小,升温速率越快,粒径约为10μm时升温速率最快。 The copolymer of PLLA-PEG-PLLA was synthesized via ring-opening polymerization of L-lactide using polyethylene glycol as initiator, and the Fe3O4 nano-partides were prepared by thermal decomposition method. The PLLA-PEG-PLLA/Fe3O4 microspheres were prepared by organic solvent evaporation method, and the morphology and size of the microspheres prepared were observed by SEM. Vibrating sample magnetometer（VSM） and Tg were employed to investigate the magnetite content and magnetic properties. It is indicated that for the microspheres with the same particle size and different magnetic content, the higher the magnetite content is, the rapider the heating rate is. The heating rate of the magnetic microspheres with the magnetite content of 70.57% is the fastest, and the temperature could rise to a effective temperature of 42 ℃ for tumor hyperthermia. For the microspheres with the same magnetic content and different particle diameters, the smaller the particle diameter is, the rapider the heating rate is. The heating rate of the magnetic microspheres with the particle diameter of about 10 μm is the fastest.

关 键 词： 聚乳酸 纳米 磁性微球 磁热效应 磁热疗