作 者: (赵吴静); (徐进强); (武中庸); (蒲万霞);
机构地区: 中国农业科学院兰州畜牧与兽药研究所,农业部兽用药物创制重点实验室,甘肃省新兽药工程重点实验室,兰州730050
出 处: 《中国畜牧兽医》 2017年第8期2458-2464,共7页
摘 要: 金黄色葡萄球菌(Staphylococcus aureus,SA)是革兰氏阳性菌,是目前临床感染常见的一种病原菌,能引起局部化脓性感染、关节炎、心内膜炎、蜂窝织炎、败血症、脓毒血症等全身感染。近些年来,由于抗生素不合理的使用,金黄色葡萄球菌的耐药性日益严重,特别是苯唑西林敏感耐甲氧西林金黄色葡萄球菌(oxacillin-susceptible methicillin-resistant Staphylococcus aureus,OS-MRSA)的出现给临床治疗增加了巨大的难度。了解OS-MRSA的流行病学特点和耐药机制可帮助临床医师更好地选择治疗药物,鉴于此,作者针对OS-MRSA的流行病学及耐药机制研究进展进行综述。 Staphylococcus aureus(S.aureus)is a gram-positive bacteria which could cause many kinds of infections,such as arthritis,endocarditis cellulitis,septicemia,pyemia and other systemic infections.In recent years,due to the unreasonable use of antibiotics,resistant Staphylococcus aureus increased rapidly.Particularly,the oxacillin-susceptible methicillin-resistant Staphylococcus aureus(OS-MRSA),it is a great challenge for clinical treatment.Understand the epidemiological characteristics and the mechanism of drug resistance of OS-MRSA can help clinicians to choose therapeutic drugs much better.This review summarized the research progress of epidemiology and resistant mechanism of OS-MRSA.
关 键 词: 苯唑西林敏感耐甲氧西林金黄色葡萄球菌 流行病学 耐药机制