作　　者： (牛万祥）; (牛朝诗）;

机构地区： 安徽医科大学附属省立医院神经外科脑功能与脑疾病安徽省重点实验室安徽省脑立体定向神经外科研究所,合肥230001

出　　处： 《中华解剖与临床杂志》 2017年第4期337-340,共4页

摘　　要： 目的 探讨胶质瘤微环境中的多种肿瘤自分泌/旁分泌因子对肿瘤细胞增殖的调控作用.方法 应用PubMed、CNKI及谷歌学术数据库以＂胶质瘤＂＂自分泌/旁分泌＂＂肿瘤增殖＂为关鍵词,查阅2004年1月-2016年5月国内外文献,就胶质瘤自分泌/旁分泌中的多种因子与胶质瘤细胞增殖之间的关系进行归纳总结.结果 胶质瘤微环境中,生长因子、细胞因子、趋化因子、非肽类因子、甾体激素等多种因子参与了肿瘤自分泌/旁分泌的信号环路,调控胶质瘤细胞增殖、侵袭、扩散等多种生物学活动.结论 对胶质瘤微环境中的自分泌/旁分泌的机制研究,为胶质瘤的发病机制研究以及临床诊断和治疗提供了新的途径. Objective To explore the regulatory effects of various types of autocrine or paracrine factors under glioma microenvironment on proliferation of glioma cells.Methods Key words including ＂glioma＂＂autocrine or＂＂ paracrine＂＂proliferation＂ were searched in PubMed;CNKI and GOOGLE SCHOLAR databases between January 2004 and May 2016,and relevant recent literatures which related with autocrine or paracrine factors and proliferation of glioma cells were reviewed.Results Multiple factors including growth factors;cytokines;chemokines;nonpeptide factors and steroid hormones participate in the autocrine or paracrine regulatory loop to play effects on proliferation;invasion;diffusion of glioma cells.Conclusions Studies on the mechanisms of autocrine or paracrine in glioma microenvironment may provide further insight into the underlying pathogenesis and may provide new potential targets for diagnosis and treatment.

关 键 词： 胶质瘤 自分泌因子 旁分泌因子 生长因子 细胞因子 趋化因子 甾体激素 肿瘤增殖