作　　者： (杨利）; (韩诗雯）; (车会莲）; (许文涛）; (黄昆仑）; (罗云波）;

机构地区： 中国农业大学食品科学与营养工程学院,北京100083 渤海大学食品科学与工程学院,辽宁锦州121013

出　　处： 《中国食品学报》 2017年第7期55-60,共6页

摘　　要： 目的:研究罗布麻茶水提物对自发性高血压大鼠(Spontaneous hypertension rat,SHR)血压的调节规律以及降压时相的出现与其它生理指标变化的关系。方法:以SHR为实验动物,每天灌胃1次受试物,每周1次采用尾套法连续测试灌胃后8~10 h内的收缩压及心率,6周后测试降压时相的体质量、尿量及尿钠、尿钾的分泌以及血脂含量。结果:与阴性对照组相比,灌胃罗布麻茶水提物后SHR收缩压(SBP)先升高后下降,这种现象在连续灌胃3周后明显,而心率无显著的规律性变化;稳定的降压时相(8 h左右)在连续灌胃3周后出现,最大降幅达16 mm Hg;降压时相SHR的体质量及血脂无显著变化(P≥0.05),尿量及尿钠、尿钾的分泌显著增加(P<0.05)。结论 :罗布麻茶水提物对SHR收缩压具有先升高后下降的双向调节作用,然而起效慢,降压时相的出现可能与其利尿及利钠、利钾作用有关。 Objective： Research the regulation of Apocynum venetum tea aqueous extract（AVTAE） on the blood pressure in spontaneously hypertensive rats（SHR） and the relationship between its lowering pressure and changing of other physiological indexes. Methods： SHR were fed the test substance once a day, and once a week, they were tested the systolic blood pressure（SBP） and heart rate within 8-10 hours using tail-cuff method after gavaged. After six weeks,their weight, urine volume, urinary sodium and potassium and blood lipid in pressure down phase were tested. Results：Compared with the negative control group, the AVTAE group showed a downward trend after the first rise of the SHR＇s SBP, and this kind of phenomenon was very significant after 3 weeks, without significant regular change of heart rate.Stable lowering pressure phase（about at 8 h） appeared after three weeks, and the biggest drop was up to 16 mm Hg; In stable lowering pressure phase, the body weight and blood lipids did not change significantly, but the urine volume and urinary sodium, potassium significantly increased. Conclusion： AVTAE can decrease blood pressure after the first rise,but this bidirectional regulation works slow. Stable lowering pressure phase（about at 8 h） may be have relationship with its diuretic, natriuretic and kaliuretic effects.

关 键 词： 罗布麻茶 自发性高血压大鼠 血压 双向调节