作　　者： (谢广云）; (陈巍）; (王全凯）; (程秀荣）; (许建宁）; (黄沛力）;

机构地区： 中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处： 《中华劳动卫生职业病杂志》 2017年第7期487-490,共4页

摘　　要： 目的探讨尾静脉注射碲化镉量子点（CdTeQDs）对小鼠体内氧化损伤的作用。方法40只雄性ICR小鼠随机分为5组，每组8只，采用尾静脉注射染毒。染毒浓度分别为0（对照）、0.5、5．0、50．0和500．0nmol／ml的cdTeQDs溶液，每只动物注射0．2ml，对照组注射等体积的生理盐水。染毒24h后处死小鼠，测定小鼠血清生化、血液常规指标以及小鼠血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性和丙二醛（MDA）含量。结果与对照组比较，0．5、5．0、50．0和500．0nmol／mlCdTeQDs染毒组的CRE、PLT水平及MDA含量均明显降低，差异有统计学意义（P〈0．05或P〈0．01）；50．0和500．0nmol／mlCdTeQDs染毒组的GSH．Px活性与对照组比较明显增高，差异有统计学意义（P〈O．01）。结论本实验条件下0．5ninol／mlCdTeQDs能够对小鼠体内产生氧化损伤作用。 Objective To investigate Oxidative damage effects induced by CdTe Quantum Dots （QDs） in mice. Methods 40 ICR mice were randomly divided into 5 groups ：one control group （normal saline） ; four CdTe QDs （exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0,0.5,5.0,50.0 and 500.0 nmol/ml respectively）. After 24 h, the mice were decapitated and the blood was collected for serum bioehemically indexes, hematology indexes, the activities of SOD ,GSH-Px and the concentration of MDA were all detected. Results The results showed in the four CdTe QDs exposure groups, the level of CRE,PLT and the concentration of MDA were all significantly lower than those of the control group （P〈0.05 or P〈0.01 ） ; the activities GSH-Px in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group （P〈0.01）. Conclusion It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in

关 键 词： 碲化镉 量子点 小鼠 超氯化物歧化酶