作　　者： (陈向华）; (王建吉）; (耿学丽）; (丁萌）; (张秀琴）;

机构地区： 承德医学院附属医院检验科,河北承德067000

出　　处： 《河北医学》 2017年第8期1278-1281,共4页

摘　　要： 目的:分析探究抗核抗体和抗核抗体谱联合检测诊断自身免疫性疾病的临床价值。方法:选取1103份送检至本院的血样,同时进行抗核抗体检测和抗核抗体谱检测,抗核抗体检测运用间接免疫荧光法进行,抗核抗体谱检测运用免疫印迹法进行,将检测结果为阳性的患者资料收集起来,进行统计学分析。结果:抗核抗体检测的血样结果为阳性的患者占所有受检患者的6.32%,经诊断,准确率为78.21%;抗核抗体谱检测的血样结果为阳性的患者占所有受检患者的4.78%,诊断结果显示,抗核抗体谱的确诊率为91.32%,同时对两种方法均显示为阳性的患者进行检查,发现准确性最高,为94.67%。结论:对患者同时进行抗核抗体检测和抗核抗体谱检测,能有效提高检测结果的准确性,值得推广。 Objective： To analyze and explore the clinical value of combined detection of antinuclear antibodies and antinuclear antibodies in the diagnosis of autoimmune diseases. Method： 1103 blood samples were submitted to our hospital,antinuclear antibody detection and antinuclear antibody spectrum detection were simultaneously tested. Antinuclear antibodies were detected by indirect immunofluorescence,and antinuclear antibodies were detected by Western blot. The data of patients with positive results were collected and analyzed statistically. Results： The positive results of antinuclear antibody test accounted for 6. 32% of all patients,and the diagnosis accuracy was 78.21%; Detection of antinuclear antibody spectrum of blood test positive patients accounted for 4.78% of all patients,the diagnosis results showed that antinuclear antibody spectrum diagnosis rate was 91.32%,and the two methods were both positive patients for inspection,found that the highest accuracy is 94.67%. Conclusion： Simultaneous detection of antinuclear antibodies and antinuclear antibody spectrum can effectively improve the accuracy of the detection results,and is worthy of promotion.

关 键 词： 抗核抗体 抗核抗体谱 联合检测 自身免疫性疾病