作　　者： (俞梅华）; (钱晓萍）;

机构地区： 湖州市疾病预防控制中心,浙江湖州313000

出　　处： 《疾病监测》 2017年第8期646-650,共5页

摘　　要： 目的了解浙江省湖州市<15岁儿童急性弛缓性麻痹(AFP)病例流行病学特征,为制定防控策略提供参考依据。方法对湖州市2004 2016年AFP病例进行描述流行病学分析,对残留麻痹影响因素进行单因素和多因素非条件logistic回归。结果 2004 2016年湖州市共报告<15岁AFP病例128例,主要为散发。年平均发病率为2.32/10万。发病高峰多出现于每年1月、3月和8 10月,0~4岁组发病率较高,男性发病率高于女性,男女性别比为2.2∶1。肠道病毒分离率为7.81%。10.16%的AFP病例在麻痹60 d后仍残留麻痹。多因素分析显示<1岁发病、深部腱反射异常是AFP残留麻痹病例发生的危险因素。结论提高儿童脊髓灰质炎疫苗接种率、加强临床医生培训、教育儿童养成良好卫生习惯、尽早对重症患者开展对症治疗,是降低儿童AFP病例致残率的有效措施。 Objective To analyze the epidemiological characteristics of acute flaccid paralysis（ AFP） in children aged 15 years in Huzhou, Zhejiang province, and explore measures for AFP control and prevention. Methods Descriptive epidemiological analysis was conducted on the related data of AFP cases in Huzhou from 2004 to 2016. The risk factors of paralysis sequela were analyzed with univariate and multivariate non-conditional logistic regression model. Results A total of128 AFP cases were reported in children aged 15 years in Huzhou during 2004-2016. The cases were mainly sporadic and the average annual incidence was 2. 32/100 000. The annual peaks were in January and March and during August-October and the incidence was highest in age grouP〈0-4 years. The gender ratio was 2. 2 ∶ 1. The enterovirus isolation rate was 7. 81%.The incidence of residual paralysis 60 days after onset was 10. 16%. The results of multivariate non-conditional logistic regression analysis showed that the risk factors for residual paralysis included age 1 year and abnormal deep tendon reflex.Conclusion It is necessary to take effective measures to reduce the incidence of residual paralysis in AFP cases,including improving OPV immunization,strengthening clinical doctor training,health education in children and timely symptomatic treatment of severe cases.

关 键 词： 急性弛缓性麻痹 脊髓灰质炎病毒 残留麻痹 回归