作　　者： (刘建清）; (施洪）; (吴国兰）; (陈雨燕）;

机构地区： 福州总医院,福州350025

出　　处： 《中国真菌学杂志》 2017年第4期225-227,共3页

摘　　要： 目的报道1例播散性隐球菌病(disseminated cryptococcosis)及相关文献复习。方法回顾性分析1例播散性隐球菌病例,检索外文生物医学期刊整合系统、CHKD期刊全文数据库等近20a国内外报道的病例,结合文献复习总结播散性隐球菌病的临床特点。结果患者女,16岁,因"咳嗽、发热10余天"入院,既往有"特发性血小板减少性紫癜"并长期口服激素治疗。经腰椎穿刺术及血培养等确诊为播散性隐球菌病,抗真菌治疗后症状好转。数据库共检索148例播散性隐球菌病,免疫功能正常宿主59例,男95例,女53例,年龄2~77岁,儿童47例,死亡41例。结论播散性隐球菌病病死亡率高,应争取早期诊断和治疗,提高治愈率,减少致残率。 Objective To report a case of disseminated cryptococcosis and review of the related literature.Methods Retrospective analysis of a case of disseminated cryptococcosis,case retrieval of Foreign Medical Journal CHKD journal full-text database integration system and nearly 20 years as reported at home and abroad, combined with literature review summarized clinical characteristics of disseminated cryptococcosis.Results A 16-year-old female presented with a over 10-day history of a cough and fever.She was originally diagnosed with idiopathic thrombocytopenic purpura and had been treated with oral corti-costeroids for a long time.Disseminated cryptococcosis was diagnosed by lumbar puncture and blood culture.A total of 149 cases of disseminated cryptococcosis were collected from the database,including male 95 cases and female 53cases,aged from 2 to 77 years old,with a total of 47 children,with a mortality of 41 cases.And there were 59 patients with normal immune function.Conclusion The mortality rate of disseminated cryptococcosis is high,so we should strive for early diagnosis and treatment, improve the cure rate and reduce the disability rate.

关 键 词： 新生隐球菌 播散性隐球菌病 免疫功能低下