作　　者： (谭平）; (罗湘贵）; (许新华）;

机构地区： 湖南机电职业技术学院,中国长沙410151

出　　处： 《湖南师范大学自然科学学报》 2017年第4期51-56,共6页

摘　　要： 以替加氟和3-对甲苯磺酰基丙炔为原料,制备出替加氟炔烃化合物,继而以廉价的氢氧化铯作为催化剂,催化替加氟炔烃和二芳基二硫(硒)醚反应,高立体、区域选择性制备硫(硒)代替加氟烯烃.该方法具有环境友好,产率高,反应条件温和,立体、区域选择性高等优点,为硫(硒)代替加氟烯烃的制备提供了一个新方法.该类硫(硒)代替加氟烯烃化合物有望成为一种有效的抗肿瘤药物. Tegafur alkynes are synthesized by using tegafur and 3-（p-toluene sulfonyl） propyne as starting materials, which were then treated with diaryl disulfides or diaryl diselenides catalyzed by cesium hydroxide monohydrate to yield S （Se）-substituted tegafur alkenes in high regio-and stereo-selectivity.This method has the advantages of environmentally friendly, high yield, mild conditions and high regio-and stereo-selectivity, providing a convenient and efficient way to obtain S （Se）-substituted tegafur alkenes, which could be used as effective drugs for cancer treatment in the future.

关 键 词： 氢氧化铯 替加氟 二芳基二硫 硒 醚 替加氟炔烃 硫 硒 代替加氟烯烃