作　　者： (杨露）; (吴棠）;

机构地区： 四川大学华西医院肿瘤一病房,四川成都610051

出　　处： 《海南医学院学报》 2017年第14期1965-1968,共4页

摘　　要： 目的:探讨新辅助化疗+营养干预对结肠癌不全性肠梗阻患者营养状况、肿瘤负荷的影响。方法:选择在本院接受治疗的中晚期结肠癌患者90例,经随机数表法分为对照组、观察组各45例。对照组接受常规新辅助化疗+手术治疗,观察组在此基础上全程接受营养干预。对比两组新辅助化疗前(T0)、新辅助化疗后(T1)、手术后3d(T2)的营养状态、肿瘤负荷差异。结果:T0时,两组外周血中营养指标含量,血清中特异性肿瘤标志物、血管新生指标含量的差异无统计学意义(P>0.05)。T1、T2时,观察组外周血中营养指标TB、Alb、Hb的含量高于对照组;血清中特异性肿瘤标志物PTN、CCSA-1的含量低于对照组;血清中血管新生指标VEGF、Ang-2的含量低于对照组患者(P<0.05)。结论:新辅助化疗+营养干预可有效改善结肠癌不全性肠梗阻患者的营养状况,有助于肿瘤负荷的进一步降低。 Objective：To explore the effect of neoadjuvant chemotherapy ＋ nutritional intervention on the nutritional status and tumor load in colon cancer patients with incomplete ileus.Methods：A total of 90 patients with middle and advanced colon cancer who were treated in the hospital were divided into control group and observation group by random number table,each with 45 cases.Control group received routine neoadjuvant chemotherapy＋ surgical treatment,and the observation group received nutritional intervention on this basis.The differences in nutritional status and tumor load between the two groups were compared before neoadjuvant chemotherapy（T0）,after neoadjuvant chemotherapy（T1）and three days after opeartion（T2）.Results：At T0,the differences in the contents of nutrition indexes in peripheral blood as well as the contents of specific tumor markers and angiogenesis indexes were not statistically significant between the two groups（P〉0.05）.At T1 and T2,peripheral blood nutrition indicators TB,Alb and Hb contents of observation group were higher than those of control group;serum specific tumor markers PTN and CCSA-1contents were lower than those of control group;serum angiogenesis indexes VEGF and Ang-2contents were lower than those of control group（P〈0.05）.Conclusions：Neoadjuvant chemotherapy＋ nutrition intervention can effectively improve the nutritional status of colon cancer patients with incomplete ileus,and help to further reduce the tumor load.

关 键 词： 结肠癌 不全性肠梗阻 新辅助化疗 营养干预 肿瘤负荷